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Lorazepam is associated with the potential for misuse and dependency, which can result in overdose and fatality. Combining this medication with alcohol or other substances that induce drowsiness or respiratory issues, particularly opioid medications such as codeine or hydrocodone, may lead to severe side effects, including death.

To mitigate risks, it is crucial for your healthcare provider to prescribe the minimal effective dose and limit the duration of lorazepam usage. Ensure you understand the correct administration of lorazepam and are aware of any drugs to avoid while taking it.

Seek immediate medical attention if you experience any of the following severe side effects: slowed or shallow breathing, unusual lightheadedness, extreme drowsiness or dizziness, or difficulty waking.

Abruptly discontinuing lorazepam may trigger serious, potentially life-threatening withdrawal symptoms, especially if used long-term or at high doses. To prevent withdrawal, your doctor may gradually reduce your dosage. Promptly inform your doctor or pharmacist if you notice any withdrawal symptoms such as headaches, insomnia, restlessness, hallucinations/confusion, depression, nausea, or seizures. Be aware that withdrawal symptoms may persist for weeks to months.

You might experience some mild side effects, such as drowsiness, dizziness, loss of coordination, headache, nausea, blurred vision, changes in sexual interest or ability, constipation, heartburn, or appetite changes. These are generally not serious and often improve as your body adjusts to the medication. However, if they persist or worsen, it is important to inform your healthcare provider.

Occasionally, more serious side effects may occur. Contact your doctor immediately if you experience significant mental or mood changes (like hallucinations, depression, or suicidal thoughts), difficulty speaking, vision changes, unusual weakness, trouble walking, memory problems, or symptoms of infection such as a persistent sore throat, fever, or chills.

In rare cases, the medication might produce severe effects, including yellowing of the eyes or skin, seizures, or slow and shallow breathing, which require urgent medical attention. On very rare occasions, the drug might have an opposite effect, resulting in agitation, irritability, violent behavior, confusion, restlessness, excitement, or excessive talking. Notify your doctor if you experience any of these reactions.

Severe allergic reactions are also rare but require immediate medical help if symptoms like rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing occur. While this list covers many potential side effects, it is not exhaustive. If you notice any other unusual symptoms, contact your healthcare provider for guidance.