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Here is a clear and professional summary of the safety and warning information related to the use of Tabrecta (capmatinib). It is essential to understand the potential risks and necessary precautions associated with this medication. Please consult your healthcare provider if you have any concerns.

• Serious Lung Issues: Tabrecta (capmatinib) may rarely cause severe lung problems such as lung inflammation or interstitial lung disease, which can be life-threatening. If you experience new or worsening breathing issues, chest pain, or a dry cough, contact your healthcare provider immediately. Your provider may advise discontinuing the medication if lung problems arise.

• Liver Concerns: This medication can elevate liver enzyme levels, potentially leading to liver complications, sometimes as early as two weeks into treatment. Regular blood tests will be required to monitor liver health. Symptoms such as fatigue, nausea, loss of appetite, dark urine, pain in the right side of the stomach, easy bruising or bleeding, or yellowing of the eyes or skin should be reported to your provider. Depending on the severity, your dosage may be adjusted or temporarily halted.

• Pancreatic Effects: Elevated pancreatic enzyme levels have been observed in some patients, which could result in pancreatitis. This typically occurs around two months after starting treatment but can happen later. Regular lab tests will be conducted to monitor enzyme levels. Notify your provider if you experience upper stomach or back pain that worsens with eating, unexplained weight loss, nausea, or vomiting. Treatment adjustments may be necessary based on the severity of the condition.

• Risks to Unborn Babies: Animal studies suggest potential harm to an unborn baby from Tabrecta (capmatinib). If you are capable of becoming pregnant, a pregnancy test might be recommended before starting treatment. It is advised to use effective birth control during treatment and for at least one week after the last dose. Inform your provider promptly if a pregnancy occurs during this period.

Ensure to adhere to these guidelines and consult your healthcare provider for any questions or concerns regarding Tabrecta (capmatinib). There are no specific contraindications listed for this medication.

When taking this medication, you may experience some common side effects, which are generally mild and manageable. These include swelling in the face, arms, or legs; nausea; joint, muscle, or bone pain; tiredness; vomiting; and changes in appetite. Some patients might also notice fluctuations in albumin, creatinine, and certain digestive enzyme levels. It’s important to monitor these symptoms and consult with your healthcare provider if they persist or worsen.

Other potential side effects include constipation, diarrhea, fever, dizziness, rash, weight loss, and cough. While these effects are typically not severe, it’s advisable to inform your healthcare provider if they become troublesome.

There are more serious side effects that require immediate medical attention. These include severe lung issues, such as trouble breathing, chest pain, or a persistent cough, as well as signs of liver or pancreas problems like persistent nausea, abdominal pain, or yellowing of the eyes or skin. Additionally, although a serious allergic reaction is rare, symptoms such as rash, severe dizziness, or swelling of the face and throat warrant urgent medical attention.

Always remain vigilant about any unusual symptoms and communicate with your healthcare provider to ensure your safety while using this medication.