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Leuprolide may cause a variety of side effects, some of which are more common and others that are rare but serious. Common side effects include hot flashes, increased sweating, night sweats, tiredness, headaches, upset stomach, and breast changes. You may also experience acne, joint or muscle aches, trouble sleeping, reduced sexual interest, vaginal discomfort or dryness, swelling of the ankles or feet, dizziness, or mild irritation at the injection site. These effects are typically mild, but if they persist or worsen, it's important to inform your healthcare provider.

While taking this medication, you should expect your menstrual period to stop or become lighter. If regular periods continue, discuss this with your healthcare provider. It's reassuring to know that most people using leuprolide do not experience serious side effects. However, be alert to any severe symptoms such as mental or mood changes like depression or mood swings, new or worsening bone pain, or easily broken bones, and report these to your healthcare provider immediately.

In rare cases, leuprolide can cause very serious side effects such as seizures, which require urgent medical attention. Additionally, although a severe allergic reaction is uncommon, it is crucial to seek immediate medical help if you experience symptoms such as fever, swollen lymph nodes, rash, severe dizziness, trouble breathing, or swelling particularly of the face, tongue, or throat. Always consult your healthcare provider if you notice any other side effects not mentioned here.