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Xtandi (enzalutamide) is a medication used to treat prostate cancer, but it comes with important safety warnings and risks. It is crucial to discuss these with your healthcare provider to ensure safe use.

• Seizures: Xtandi can lead to seizures, although this is uncommon. Inform your healthcare provider if you have a history of seizures or conditions that increase seizure risk, such as head injuries, strokes, or if you are on medications that could trigger seizures. Early signs may include unusual taste or smell, anxiety, nausea, or a fluttering sensation. If a seizure occurs, discontinue Xtandi and seek medical advice promptly, as a different treatment may be necessary.

• Posterior Reversible Encephalopathy Syndrome (PRES): Rarely, Xtandi may cause a condition known as PRES, which involves swelling of brain blood vessels. Symptoms include sudden severe headaches, confusion, vision changes, behavioral changes, or seizures. Immediate medical attention is required, and discontinuation of the medication is necessary if PRES occurs.

• Heart Problems: Xtandi can restrict blood flow around the heart, potentially causing serious issues like heart attacks. If you have existing heart conditions or risks such as high blood pressure, diabetes, or high cholesterol, close monitoring by your healthcare provider is advisable. Seek immediate medical help if you experience chest pain, rapid heartbeat, shortness of breath, arm or shoulder pain, sweating, or dizziness.

• Falls and Fractures: There is an increased risk of falls and bone fractures with Xtandi. Your provider may monitor you more closely and recommend medication to fortify your bones. Report any bone pain or increased incidence of falls to your provider.

• Potential Harm to Unborn Babies: Xtandi can be harmful to unborn children. If your partner can become pregnant, use effective birth control, such as condoms, while on Xtandi and for three months following the last dose. Inform your provider if a pregnancy occurs during this period.

These warnings highlight the importance of careful consideration and communication with healthcare providers when using Xtandi to manage prostate cancer.

When taking this medication, some common side effects might include hot flashes, headache, dizziness, and a decreased interest or ability in sexual activities. These effects are usually mild, but if they persist or worsen, it is advisable to consult your healthcare provider. Other commonly reported side effects are weakness or fatigue, back pain, constipation, diarrhea, joint pain, reduced appetite, and high blood pressure. Monitoring your blood pressure regularly is important, as this medication may cause an increase.

In some instances, individuals might experience swelling in the arms or legs, muscle or bone discomfort, nausea, or issues with memory and concentration. Lung infections, falls, bone fractures, and blood in the urine have also been observed. Although these are less common, they should be addressed if they occur.

There are serious side effects that, although rare, require immediate medical attention. These include persistent or severe headaches, seizures, sudden changes in vision, confusion, heart-related symptoms like chest or arm pain, shortness of breath, unusual sweating, and severe allergic reactions such as rash, swelling, or trouble breathing. Additionally, this medication might lower your ability to fight infections, increasing the risk of serious infections. If you experience symptoms like a persistent sore throat, fever, or chills, seek medical advice promptly. Always stay vigilant for any unusual symptoms and contact your healthcare provider if needed.