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Emcyt (estramustine) is a medication used in the treatment of prostate cancer. It is important to be aware of the following safety information and warnings associated with its use. If you have any questions or concerns, please consult your healthcare provider.

• Risk of Blood Clots: Estrogen treatments like Emcyt can increase the risk of blood clots, which in rare cases, can lead to heart attacks. Inform your healthcare provider if you have a history of blood clots, especially those that developed during estrogen therapy, or if you have experienced a stroke or have coronary artery disease. Seek immediate medical attention if you notice chest pain, irregular heartbeats, shortness of breath, dizziness, confusion, difficulty in walking, slurred speech, vision changes, or severe headaches.

• Elevated Blood Sugar: Emcyt may impede your body's ability to control blood sugar levels, possibly leading to hyperglycemia. If you have diabetes, work with your provider to closely monitor your blood sugar. Report symptoms such as increased thirst or hunger, frequent urination, headaches, or blurred vision to your healthcare provider.

• Increased Blood Pressure: This medication can cause a rise in blood pressure. Your doctor may advise regular monitoring of your blood pressure. Notify them if you experience severe headaches, irregular heartbeat, fatigue, or dizziness.

• Fluid Retention and Heart Issues: Emcyt may lead to fluid retention in the arms or legs, or exacerbate heart failure. Symptoms include shortness of breath, weight gain, leg or ankle swelling, fatigue, and decreased appetite. Inform your doctor if you have conditions like seizures, migraines, or kidney problems that could worsen with fluid retention.

Contraindications:

• Avoid using Emcyt if you have allergies to estradiol or nitrogen mustard, or have problems related to blood clots.

Always discuss your medical history and any existing conditions with your healthcare provider to ensure Emcyt is safe for you. In the case of an overdose or severe reactions, seek emergency medical help immediately.

When taking this medication, you may experience some common side effects, which are usually mild. These include nausea, vomiting, diarrhea, stomach upset, loss of appetite, dry skin, headache, leg cramps, decreased sexual interest or ability, and male breast tenderness or enlargement. Some individuals may also notice higher liver enzymes, swelling or fluid buildup, difficulty breathing, passing gas, weakness, mood changes, difficulty sleeping, anxiety, throat irritation or hoarseness, rash, itching, bruising, or thinning hair. If any of these effects persist or worsen, it's advisable to consult a healthcare provider.

There are also serious side effects that, although rare, demand immediate medical attention. These include signs of a heart attack, such as chest pain, shortness of breath, sweating, and dizziness; symptoms of a stroke, like sudden confusion, numbness or weakness on one side of the body, and severe headache; and indications of blood clots in the lungs or veins, which can present as chest pain, racing heart, swelling in limbs, and red or discolored skin. It's crucial to seek urgent medical care if you experience any of these severe symptoms.

Additionally, this medication may affect your body’s ability to fight infections. If you develop signs of an infection, such as a persistent sore throat, fever, or chills, contact your healthcare provider promptly. Lastly, although very rare, serious allergic reactions can occur. Symptoms like rash, itching/swelling particularly of the face, tongue, or throat, severe dizziness, and trouble breathing require immediate medical help. Always discuss any unexpected side effects with your doctor or pharmacist to ensure your safety and well-being.

Emcyt (estramustine) can interact with various medications and supplements, potentially affecting your treatment. It's crucial to inform your doctor and pharmacist about all the medications you are taking, whether they are prescription, over-the-counter, vitamins, or herbal supplements.

Certain drugs, such as aromatase inhibitors (e.g., anastrozole, exemestane), corticosteroids (e.g., prednisolone), ospemifene, tamoxifen, and tranexamic acid, may interact with Emcyt. Additionally, medicines for low thyroid (hypothyroidism) like levothyroxine, could also pose a risk when combined with Emcyt.

Some medications can alter estrogen levels in your body, which is significant for those taking Emcyt. These include azole antifungals (such as itraconazole, ketoconazole), a variety of antibiotics (including cephalosporins, macrolides, penicillins, tetracyclines, sulfas), as well as other drugs such as aprepitant, bexarotene, bosentan, dapsone, griseofulvin, certain HIV protease inhibitors (such as nelfinavir), modafinil, nevirapine, rifamycins (like rifampin), ritonavir, many seizure medications (such as barbiturates, carbamazepine, phenytoin, primidone, topiramate), and St John's wort.

Furthermore, using Emcyt together with medications like amifampridine, bupropion, and donepezil is generally not recommended unless absolutely necessary. If these are prescribed together, your healthcare provider may adjust the dosage or frequency of one or both medicines to manage any potential risks. Always follow your healthcare provider's instructions and report any unusual side effects.