Flutamide

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generic Eulexin

Flutamide is prescribed for the treatment of prostate cancer, specifically when the cancer has spread to other parts of the body (metastatic prostate cancer). This medication is part of a group of drugs known as anti-androgens or androgen receptor inhibitors. It works by blocking the effects of testosterone, a hormone that prostate cancer cells rely on to grow and spread. By inhibiting testosterone, Flutamide helps to slow down the progression and spread of prostate cancer. It is taken orally three times a day. Some common side effects include hot flashes and a decrease in sexual drive. Always consult with your healthcare provider before starting any new medication to ensure it is safe and suitable for your condition.
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125MG, Flutamide (30 Capsules)

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CVS

$27.72

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Walgreens

$29.33

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Rite Aid

$34.09

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Albertsons

$62.22

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$27.72

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Flutamide dosage forms

The average cost for 30 Capsules of Flutamide (generic Eulexin) at 125MG is $27.75 with a free coupon. This is 22.67% off the average retail price of $122.41
DosageQuantityPrice fromPer unit
125MG30 Capsules$27.75$0.93

Flutamide Warnings

Flutamide, a medication used for specific medical conditions, carries important safety information that must be understood by both patients and healthcare providers. Adhering to the following guidelines can help mitigate potential risks associated with its use:

  • Liver Health Concerns: Flutamide has been associated with rare but severe liver complications, which can be life-threatening. These issues are more likely to occur within the first three months of treatment. Patients should be vigilant for symptoms such as persistent nausea, vomiting, abdominal pain, loss of appetite, extreme tiredness, dark urine, yellowing of the skin or eyes, muscle aches, and joint pain. If these symptoms arise, immediate medical consultation is imperative. Regular monitoring of liver function through blood tests is advised, and all medical appointments should be kept. Alcohol consumption should be avoided during treatment with flutamide.

  • Interactions with Warfarin: There is an increased risk of bleeding for patients taking both flutamide and the blood thinner warfarin (Coumadin). Bleeding complications can occur even if the patient was previously stable on warfarin. Close monitoring of blood work (INR tests) is necessary to ensure appropriate dosing. Seek urgent medical attention if experiencing signs of serious bleeding, such as sudden weakness, severe headache, confusion, dizziness, seizures, vision changes, loss of balance, slurred speech, vomiting blood, or black, tarry stools.

  • Potential Toxicity: Although it is very rare, flutamide may cause serious toxicity, leading to rapid destruction of red blood cells (hemolytic anemia), insufficient oxygen circulation (methemoglobinemia), or liver issues like cholestatic jaundice. Individuals who smoke or have specific genetic blood conditions, such as hemoglobin M disease, are at higher risk. Symptoms to watch for include dizziness, tiredness, weakness, difficulty breathing, stomach pain, fever, nausea, vomiting, and yellowing of the skin or eyes.

  • Contraindications: Flutamide should not be used by individuals with severe liver problems due to the increased risk of adverse effects.

Patients are advised to discuss any concerns or symptoms with their healthcare provider promptly and to follow all medical advice related to the use of flutamide.

Flutamide Side Effects

Common side effects:

  • Hot flashes
  • Decrease in sexual interest or ability
  • Diarrhea
  • Nausea
  • Vomiting
  • Enlargement of male breasts

Less common but important to monitor:

  • Drowsiness
  • Rise in blood pressure
  • Loss of appetite
  • Depression
  • Anxiety
  • Nervousness

Serious side effects:

  • Severe liver issues
  • Confusion
  • Severe tiredness
  • Pale skin
  • Bluish nails
  • Fast heartbeat
  • Severe allergic reaction

Flutamide Interactions

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Pexidartinib

Interactions with low risk that usually do not require a change in therapy:

  • Testosterone (patch, gel, injection)
  • Anabolic steroids
  • DHEA
  • Warfarin
Flutamide FAQs
Why was flutamide discontinued?

Flutamide was discontinued in some regions primarily due to concerns about its safety profile, particularly the risk of severe liver toxicity. While it was used as an anti-androgen for prostate cancer treatment, the availability of newer medications with improved safety and efficacy profiles also contributed to its discontinuation.

Flutamide is a nonsteroidal antiandrogen that works by inhibiting the action of androgens (male hormones) at the receptor level. It competes with androgens, such as testosterone and dihydrotestosterone, for binding to androgen receptors in target tissues. By blocking these receptors, flutamide prevents the androgens from exerting their effects, which is particularly useful in conditions like prostate cancer where androgen stimulation promotes tumor growth.

Yes, flutamide can cause erectile dysfunction as a potential side effect. Flutamide is an anti-androgen medication, and by blocking the effects of androgens, it can impact sexual function, including the ability to achieve or maintain an erection. If someone experiences this side effect, they should consult their healthcare provider for further evaluation and management.

Flutamide inhibits androgen receptors. It is an antiandrogen medication that blocks the action of androgens, such as testosterone, by preventing them from binding to their receptors.

Androgen receptor inhibitors are a class of medications that block the action of androgens, which are male hormones like testosterone, by binding to androgen receptors. These inhibitors are commonly used in the treatment of conditions such as prostate cancer, where they help to slow the growth of cancer cells that rely on androgens to proliferate.