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Mitotane

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generic Lysodren

Mitotane, marketed under the name Lysodren, is an oral medication used to treat advanced cancer of the adrenal glands. It works by slowing down the growth of or killing cancerous cells in the adrenal gland and reducing the production of hormones by the gland. While the precise mechanism of action is not fully understood, it is believed to lower the activity of the adrenal gland’s outer layer, which produces essential hormones. Mitotane is typically taken multiple times a day and may cause side effects such as nausea and vomiting. Regular blood tests are necessary during treatment to monitor the drug levels in your body. Always consult with your healthcare provider for personalized medical advice.
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Mitotane WarningsMitotane Side EffectsMitotane InteractionsFAQs

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1GM of 1, Mitotane (1 Bottle)

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CVS

$152.20

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$122.58

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$126.85

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$133.57

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CVS

$152.20

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Mitotane dosage forms

The average cost for 1 Bottle of Mitotane (generic Lysodren) at 1GM of 1 is $122.58 with a free coupon. This is 25.22% off the average retail price of $486.03
DosageQuantityPrice fromPer unit
1GM of 11 Bottle$122.58$122.58

Mitotane Warnings

This drug safety information outlines crucial warnings about the use of Lysodren (mitotane). Review these points carefully and speak with your healthcare provider if you have any questions or concerns.

  • Adrenal Gland Issues: Lysodren (mitotane) may impair adrenal gland function, leading to insufficient cortisol production. Cortisol is vital for stress management. Your healthcare provider will monitor hormone levels regularly through blood tests. Steroid medication might be necessary to maintain hormonal balance.

  • Effects on the Brain and Nervous System: Possible side effects of Lysodren (mitotane) include drowsiness, weakness, and dizziness, particularly at higher medication levels in the bloodstream. Your healthcare provider will conduct blood tests to monitor Lysodren (mitotane) levels and may adjust your dosage to reduce these side effects.

  • Risks to Unborn Babies: Lysodren (mitotane) can harm an unborn child or increase miscarriage risk. Females who can conceive should use birth control while on this medication and continue until a healthcare provider confirms it is safe to stop. The drug can remain in the body after treatment ends. Immediate notification to your provider is necessary if pregnancy occurs during or after treatment.

  • Ovarian Cysts in Premenopausal Females: Some premenopausal individuals have developed ovarian cysts during Lysodren (mitotane) treatment. Symptoms such as unusual vaginal bleeding or pelvic pain should be reported to your provider, as they may indicate an ovarian cyst. These symptoms might subside after discontinuing the medication.

Mitotane Side Effects

Common side effects:

  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Feeling of imbalance or spinning surroundings
  • Depression
  • Rash

Less common but important to monitor:

  • Confusion
  • Headaches
  • Weakness
  • Slurred speech
  • Vision problems
  • Liver issues
  • Low thyroid levels (hypothyroidism)
  • Increased risk of infection
  • Increased risk of bleeding
  • Breast enlargement or tenderness

Serious side effects:

  • Adrenal crisis symptoms (severe lightheadedness, dizziness, weakness, sweating, stomach pain, nausea, vomiting, loss of consciousness)

Mitotane Interactions

This medication can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include cobicistat, doravirine, isavuconazonium, lurasidone, naldemedine, nifedipine, ranolazine, tamoxifen, voriconazole, among others. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well. Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and opioid pain relievers (such as codeine, hydrocodone). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Mitotane FAQs
What is mitotane used for?

Mitotane is used primarily to treat adrenocortical carcinoma, a type of cancer that affects the adrenal glands. It works by inhibiting the production of certain hormones and has a cytotoxic effect on adrenal cortex cells.

Yes, mitotane is considered a type of chemotherapy. It is used primarily to treat adrenocortical carcinoma, a type of cancer affecting the adrenal glands.

Mitotane works by inhibiting the adrenal cortex's ability to produce steroid hormones. It primarily affects the adrenal gland by causing atrophy of the zona fasciculata and zona reticularis, leading to decreased production of cortisol and other adrenal steroids. Additionally, mitotane alters the peripheral metabolism of steroids, contributing to its therapeutic effects in conditions like adrenocortical carcinoma.

Mitotane is used in dogs to treat Cushing's disease, which is caused by an overproduction of cortisol. It works by selectively destroying part of the adrenal cortex, thereby reducing the production of cortisol and alleviating the symptoms associated with the disease.

Chemotherapy for adrenal gland cancer may include drugs such as mitotane, which is specifically used for adrenal cancer, often in combination with other chemotherapy agents like etoposide, doxorubicin, and cisplatin. The specific regimen can vary based on the individual case and the oncologist's treatment plan.

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