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This document provides essential safety and warning information for Motpoly XR (lacosamide). Please carefully review these details and consult your healthcare provider if you have any questions or concerns.

• Suicidal Thoughts or Behavior: Taking Motpoly XR (lacosamide) may increase the risk of suicidal thoughts or self-harm, which can emerge as soon as one week after starting the medication and persist throughout treatment. If you or anyone observes signs of suicidal thoughts or unusual behavior such as anxiety, panic attacks, insomnia, irritability, or restlessness, seek medical assistance immediately. This risk may be heightened if you are also taking other anti-seizure medications.

• Cognitive and Motor Impairment: Motpoly XR (lacosamide) can cause side effects including difficulty with speech, concentration, coordination, dizziness, and sleepiness. These effects may impair your ability to think, react, and focus, and are more likely if you consume alcohol or take other medications that cause drowsiness, such as benzodiazepines, muscle relaxants, or sleep aids. Do not drive or engage in activities requiring full concentration until you understand how Motpoly XR affects you. Consult your healthcare provider if these issues interfere with your daily life.

• Heart Rhythm Issues: Though uncommon, Motpoly XR (lacosamide) may cause heart rhythm problems, such as atrial fibrillation or flutter. Inform your healthcare provider if you have a history of heart rhythm abnormalities before starting this medication. If you experience chest pain, dizziness, weakness, or shortness of breath while on Motpoly XR, contact your provider immediately.

• Severe Allergic and Skin Reactions: Rare but serious reactions, including Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), can occur. Symptoms may include skin changes like rash, blisters, or peeling, swollen lymph nodes, fever, dark urine, facial swelling, or difficulty breathing. Discontinue use and seek immediate medical care if any of these symptoms arise.

• Withdrawal Seizures: Do not abruptly stop taking Motpoly XR (lacosamide), as this may lead to the recurrence of seizures. Consult your healthcare provider for guidance on gradually reducing the dose.

There are no specific contraindications listed for Motpoly XR (lacosamide). Always discuss your medical history and any concurrent medications with your healthcare provider to ensure safe use of this medication.

When taking this medication, some common side effects may arise as your body adjusts. These include dizziness, headache, nausea, blurred or double vision, vomiting, sleepiness, fatigue, and problems with movement or coordination. These effects are typically mild and should not cause concern unless they persist or worsen, in which case consulting a healthcare provider is advised.

In addition to the common side effects, other experiences such as diarrhea, shakiness, memory difficulties, depression, a spinning sensation, and itching have been reported. If any of these occur, it is important to monitor their severity and discuss them with your healthcare provider if they become troublesome.

There are rare but serious side effects that necessitate immediate medical attention. These include suicidal thoughts or behaviors and abnormal heart rhythms, which can manifest as chest pain, irregular heartbeat, and difficulty breathing. Serious allergic reactions, although uncommon, can also occur, characterized by symptoms like hives, rash, fever, swelling, and trouble breathing. It is crucial to seek urgent medical care if any of these severe symptoms are experienced. Always remain vigilant and report any unusual or severe side effects to your healthcare provider promptly.