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This safety and warning information is essential for understanding the potential risks associated with the use of Mytesi (crofelemer). Please read the following points carefully and consult a healthcare professional if you have any questions or concerns:

• Potential Risk of Worsening Diarrhea: Mytesi (crofelemer) is not suitable for treating infectious diarrhea. Using it in such cases can delay the appropriate treatment and potentially worsen the condition. It is designed only to alleviate symptoms of diarrhea, not to address the underlying infection.

• Consultation for Persistent Symptoms: If you do not experience an improvement in your diarrhea symptoms within the first few weeks of using Mytesi (crofelemer), it is important to contact your healthcare provider for further evaluation and guidance.

There are no specific contraindications listed for Mytesi (crofelemer) at this time. Always discuss your medical history and current medications with your healthcare provider to ensure this medication is safe for you.

When taking this medication, you may experience some mild side effects such as a stuffy or runny nose, cough, sore throat, or sneezing. These are common and usually not a cause for concern, but if they persist or worsen, it's important to consult your healthcare provider. Additionally, some individuals might encounter upper respiratory tract infections, chest colds, back or joint pain, and nausea. These effects are often mild but should be monitored.

Other potential side effects include urinary tract infections, common colds, muscle pain, hemorrhoids, stomach infections, anxiety, and bloating. There may also be a slight rise in bilirubin levels or liver enzymes, which should be discussed with your healthcare provider if noticed.

While very serious allergic reactions to this drug are rare, it is crucial to be vigilant. Seek immediate medical attention if you experience symptoms such as a rash, severe dizziness, trouble breathing, or swelling, particularly of the face, tongue, or throat. Always keep an open line of communication with your healthcare provider regarding any unusual or severe symptoms you may experience.