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This medication comes with important safety and warning information that is essential for your health. Please read the following points carefully and discuss any concerns with your healthcare provider:

• Vaginal Yeast Infections: Using metronidazole vaginal gel can increase the likelihood of developing vaginal yeast infections by disrupting the natural balance of bacteria in the vagina. If you experience symptoms such as redness, pain, burning, or thick, white discharge, consult your healthcare provider as these may indicate a yeast infection that requires treatment.

• Nervous System Issues: There have been reports of nervous system complications, such as seizures, numbness, tingling of the hands and feet, and eye damage, in individuals using oral or intravenous metronidazole. If you have a history of nervous system problems, inform your healthcare provider prior to using metronidazole vaginal gel to assess your risk.

• Potential Cancer Risk: Animal studies have suggested a link between oral metronidazole and cancer. Although this has not been specifically studied with metronidazole vaginal gel, its absorption in the body is significantly lower compared to the oral form. Use the gel exactly as prescribed and discuss any cancer-related concerns with your healthcare provider.

Contraindications: Do not use this medication under the following conditions, as it may lead to serious health risks:

• Allergy to parabens.
• Recent use of disulfiram (Antabuse) within the last two weeks.
• Consumption of alcohol while using this medication.

If any of these conditions apply to you, or if you have any concerns, it is crucial to speak with your healthcare provider before beginning treatment.

When taking this medication, some individuals may experience mild side effects like stomach discomfort, headache, or dizziness. These are generally not a cause for concern, but you should consult your healthcare provider if they persist or worsen. Vaginal symptoms such as discomfort, itching, or discharge may also occur and could indicate a new infection, like a yeast infection. If you notice changes in vaginal discharge or new symptoms, it is advisable to seek medical advice.

More serious side effects, though rare, require immediate medical attention. These include numbness or tingling in the hands or feet and seizures. Additionally, watch for signs of a serious allergic reaction, which are uncommon but can manifest as persistent fever, new or worsening swelling of the lymph nodes, rash, significant itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing.

Remember that while many people do not experience severe side effects, it's essential to be vigilant and report any new or unusual symptoms to your healthcare provider. Your well-being is a priority, and prompt communication with your healthcare provider can help manage any side effects effectively.

Do not use this medication if you have taken disulfiram within the last 14 days. It is also important to avoid consuming alcohol or products containing propylene glycol while using this medication and for at least 24 hours after discontinuation. Consult your pharmacist for further guidance. This medication may affect certain laboratory tests, potentially leading to incorrect results. Ensure that all medical personnel and your healthcare providers are aware that you are using this drug.

Metronidazole vaginal gel can interact with various medications and supplements. Inform your doctor and pharmacist about all the medications and supplements you are currently taking, including prescription, over-the-counter, vitamins, and herbal products. While not exhaustive, the following interactions are noteworthy:

• Do not use this medication with Amprenavir, Bepridil, Cisapride, Dronabinol, Dronedarone, Mesoridazine, Pimozide, Saquinavir, Sparfloxacin, Terfenadine, Thioridazine, or Ziprasidone, as combining these can be harmful.

• Caution is advised when using this medication with Alfuzosin, Amiodarone, Amitriptyline, Anagrelide, Apomorphine, Aripiprazole and its derivatives, Arsenic Trioxide, Asenapine, Astemizole, Atazanavir, Azithromycin, Bedaquiline, Buprenorphine, Bupropion, Buserelin, Busulfan, Capecitabine, Ceritinib, Chloroquine, Chlorpromazine, live Cholera Vaccine, Ciprofloxacin, Citalopram, Clarithromycin, Clofazimine, Clomipramine, Clozapine, Crizotinib, Cyclobenzaprine, and many others. Your doctor may adjust dosages if these are prescribed together.

• Be aware that using this medication with Carbamazepine, Cholestyramine, Cyclosporine, Lithium, or Milk Thistle may elevate the risk of side effects, although it may be necessary for your treatment. Your doctor might modify the dosage or frequency of use for one or both medications.

Always communicate openly with your healthcare team about all medications and supplements you are taking to prevent adverse interactions.