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It is crucial to understand the safety information and warnings associated with the use of loperamide (Imodium A-D) to avoid potential health risks. Below are important details to consider before and during the use of this medication:

• Potential Heart Risks: Overuse or misuse of loperamide can lead to severe heart rhythm problems, which might result in fast or irregular heartbeat and, in extreme cases, death. Individuals with a history of heart rhythm issues, older adults, and those taking other heart-affecting medications are at increased risk. Always adhere to the prescribed dosage and do not exceed the recommended amount.

• Age Restrictions: This medication is not safe for children under 2 years of age due to a heightened risk of serious side effects, including slow or shallow breathing and irregular heartbeat.

• Gastrointestinal Concerns: Loperamide can slow gut movement, causing potential build-up of gas and liquids. Discontinue use and consult a healthcare provider if constipation, bloating, or stomach swelling occurs.

• Severe Allergic Reactions: Rare but serious allergic reactions might occur. Seek immediate medical attention if you experience swelling of the face, tongue, lips, or throat, have difficulty breathing, or develop a rash.

• Contraindications: Avoid using this medication if you are experiencing:

  • Stomach pain without diarrhea
  • Blood in stools or high fever
  • Active ulcerative colitis
  • Certain bacterial infections in the gut or colon

• Drug Interactions: Taking loperamide with other medications can lead to adverse effects, particularly those affecting heart rhythm. Consult your healthcare provider regarding any other drugs you are taking.

• Overdose Instructions: In case of overdose, immediate medical intervention is crucial. Seek emergency help if excessive amounts of the medication have been consumed.

Always consult with your healthcare provider for personalized advice and report any concerns or unusual symptoms promptly.

Common side effects:

• Dizziness
• Drowsiness
• Tiredness
• Constipation

Less common but important to monitor:

• Nausea
• Stomach cramps

Serious side effects:

• Severe constipation
• Severe nausea
• Vomiting
• Stomach or abdominal pain
• Uncomfortable fullness or swelling of the stomach
• Fast or irregular heartbeat
• Severe dizziness
• Fainting
• Rash
• Itching
• Swelling of the face, tongue, or throat
• Trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Amiodarone
• Chlorpromazine
• Haloperidol
• Methadone
• Moxifloxacin
• Pentamidine
• Procainamide
• Quinidine
• Sotalol
• Thioridazine
• Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Capmatinib
• Lasmiditan
• Saquinavir
• Simeprevir
• Venetoclax
• Gemfibrozil