Naltrexone Hcl Dihydrate Coupons & Savings Card – Discount Prices from $64.05

When considering the use of naltrexone hydrochloride dihydrate, it's important to be aware of several significant risks associated with its administration:

Hepatotoxicity (Liver Damage): Naltrexone has the potential to cause liver injury, particularly when taken in doses higher than recommended. Elevations in liver enzymes have been observed, indicating possible liver stress or damage. Therefore, individuals with acute hepatitis or liver failure should not use naltrexone. Patients with active liver disease must carefully consider the risks, as the margin between a safe dose and one that could cause liver injury is relatively narrow. If symptoms such as abdominal pain lasting more than a few days, light-colored stools, dark urine, or yellowing of the eyes occur, it's crucial to stop taking naltrexone immediately and consult a healthcare provider.

Precipitated Opioid Withdrawal: Administering naltrexone to someone who is currently dependent on opioids can trigger sudden and severe withdrawal symptoms. To avoid this, individuals should be free from opioids for at least 7 to 10 days before starting naltrexone. In some cases, a naloxone challenge test may be conducted to ensure that opioids are no longer present in the system. This precaution helps prevent the onset of acute withdrawal symptoms, which can be severe enough to require hospitalization.

Increased Sensitivity to Opioids: After discontinuing naltrexone, individuals may experience heightened sensitivity to opioids. This means that even lower doses of opioids than previously used can lead to life-threatening situations, such as respiratory arrest or circulatory collapse. There have been reports of fatal overdoses occurring in patients who resumed opioid use after stopping naltrexone. It's essential to inform family members and close contacts about this increased sensitivity and the associated risks.

Depression and Suicidality: There have been reports of depression, suicidal thoughts, and suicide attempts in individuals using naltrexone for opioid dependence. While a direct causal relationship hasn't been established, it's important to monitor for signs of depression or suicidal thinking. Families and caregivers should be vigilant and report any concerning symptoms to healthcare providers promptly.

Use in Specific Populations: Caution is advised when prescribing naltrexone to individuals with renal impairment, as the drug and its metabolites are primarily excreted through the kidneys. Additionally, the safety of naltrexone in pregnant women has not been well established. Therefore, it should only be used during pregnancy if the potential benefits justify the potential risks to the fetus.

Given these risks, it's imperative to use naltrexone under the guidance of a qualified healthcare professional who can provide appropriate monitoring and support throughout the treatment process.

Naltrexone hydrochloride dihydrate is a medication used to manage alcohol and opioid dependence. While it can be effective in treatment, it's important to be aware of potential side effects, which can range from mild to severe. Common Side Effects:

• Gastrointestinal Issues: Nausea, vomiting, stomach cramps, diarrhea, and constipation are frequently reported.
• Neurological Symptoms: Headaches, dizziness, drowsiness, and difficulty sleeping may occur.
• Musculoskeletal Discomfort: Joint and muscle pain are common complaints.
• Psychological Effects: Some individuals experience anxiety, nervousness, irritability, or mood changes. Less Common Side Effects:
• Skin Reactions: Rash, itching, or hives may develop.
• Respiratory Issues: Cough, hoarseness, nasal congestion, or sneezing can occur.
• Appetite Changes: Some people report a decrease in appetite. Serious Side Effects:
• Liver Damage: Naltrexone can cause liver injury, especially at higher doses. Symptoms include persistent stomach pain, dark urine, yellowing of the skin or eyes (jaundice), and unusual fatigue.
• Depression and Suicidal Thoughts: There have been reports of depression, suicidal ideation, and suicide attempts in individuals taking naltrexone. It's crucial to monitor mood changes and seek immediate medical attention if such symptoms arise.
• Allergic Reactions: Severe allergic responses, though rare, can occur. Signs include swelling of the face, lips, tongue, or throat, difficulty breathing, and severe dizziness.
• Injection Site Reactions: For those receiving the injectable form, reactions at the injection site such as pain, swelling, or tissue damage have been reported. Important Considerations:
• Opioid Withdrawal: Starting naltrexone while opioids are still in your system can precipitate acute withdrawal symptoms. Ensure a sufficient period has passed since the last opioid use before beginning treatment.
• Increased Sensitivity to Opioids: After discontinuing naltrexone, individuals may have heightened sensitivity to opioids, increasing the risk of overdose if opioids are used. Always discuss potential side effects and any concerns with your healthcare provider before starting naltrexone. They can provide guidance tailored to your health history and monitor for any adverse reactions during treatment.

When taking naltrexone hydrochloride dihydrate, it's important to be aware of potential interactions with other substances:

Opioids: Naltrexone blocks the effects of opioids. Using opioids while on naltrexone can lead to withdrawal symptoms. Avoid opioid-containing medications, including certain pain relievers, cough syrups, and antidiarrheal drugs.

Alcohol: Both naltrexone and alcohol can affect liver function. Combining them may increase the risk of liver damage. It's advisable to limit or avoid alcohol consumption during naltrexone treatment.

Disulfiram: This medication, used to treat alcohol dependence, can also impact the liver. Using disulfiram with naltrexone may heighten the risk of liver issues. Consult your doctor before combining these treatments.

Thioridazine: Combining naltrexone with thioridazine, an antipsychotic, may increase drowsiness. Monitor for excessive sedation if these medications are used together.

Cough and Cold Medications: Some over-the-counter remedies contain opioids like dextromethorphan. Naltrexone may reduce their effectiveness. Check labels and consult your pharmacist before use.

Antidiarrheal Medications: Medications containing opioids, such as diphenoxylate, may be less effective when taken with naltrexone. Consider alternative treatments for diarrhea.

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Regular use of high doses of NSAIDs with naltrexone may lead to liver enzyme elevations. Use NSAIDs cautiously and under medical supervision.

Herbal Supplements: Certain supplements, like St. John's Wort, may interact with naltrexone. Always inform your healthcare provider about any supplements you're taking.

Before starting naltrexone, inform your doctor about all medications, supplements, and substances you use to avoid potential interactions.