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The following safety information highlights important considerations and potential risks associated with the use of Nufola. Please review these details and discuss any concerns with your healthcare provider.

• Overdose Risks: Taking an excessive amount of Nufola can lead to severe side effects due to high levels of folate, vitamin B6, or vitamin B12. Always adhere to your healthcare provider's dosage instructions, and consult them if you experience symptoms like tingling in the limbs, nausea, dizziness, or sleep disturbances. The risk increases with doses higher than recommended.

• Interactions with Other Medications: The components of Nufola may interact with various medications and supplements. Folate can reduce the effectiveness of drugs such as methotrexate and anti-seizure medications. Vitamin B6 may exacerbate side effects of amiodarone and reduce the efficacy of phenytoin, potentially increasing seizure risk. Additionally, alpha-lipoic acid might lower blood sugar levels excessively when taken with diabetes medications. Discuss all medications you are taking with your provider or pharmacist before starting Nufola to avoid potential interactions.

• Anemia Concerns: Since Nufola contains folate, it could mask symptoms of pernicious anemia, a condition caused by low vitamin B12. Those with a history of low vitamin B12 should inform their healthcare provider and avoid using Nufola as a standalone treatment.

• Contraindications: Nufola should be avoided in certain populations due to potential health risks. These include:

  • Children
  • Women of childbearing age, those who are pregnant, or breastfeeding
  • Individuals with low thiamine levels

If any of these conditions apply to you, consult your healthcare provider before using Nufola.

When considering the use of Nufola, it's important to be aware of potential interactions with other medications. Nufola contains vitamins and antioxidants that can affect how certain drugs work in your body. Here are some key interactions to keep in mind:

• Fluorouracil: Folic acid in Nufola may enhance the effects of fluorouracil, increasing the risk of serious side effects such as anemia, bleeding problems, infections, and nerve damage. Symptoms to watch for include severe nausea, vomiting, diarrhea, unusual bleeding or bruising, and numbness or tingling in the hands and feet. Consult your doctor if you experience any of these symptoms.

• Pafolacianine: Taking multivitamins like Nufola may reduce the effectiveness of pafolacianine in detecting cancer tissue. It's recommended to stop taking multivitamins 48 hours before receiving pafolacianine. Discuss this with your healthcare provider for personalized advice.

• Cephalexin: While no direct interactions have been identified between Nufola and cephalexin, it's advisable to take multivitamins at least three hours after cephalexin. This spacing helps ensure optimal absorption and effectiveness of both medications.

Additionally, Nufola's components can interact with other medications:

• Vitamin B6: May affect the efficacy of Phenytoin, a seizure medication, potentially increasing the risk of seizures.

• Alpha-Lipoic Acid: Can influence blood sugar levels, which is important for individuals managing diabetes.

To minimize risks, inform your healthcare provider about all medications, supplements, and vitamins you're currently taking before starting Nufola. This ensures safe and effective use tailored to your health needs.