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Here are important safety considerations and warnings related to the use of this medication. Please read them carefully and consult your healthcare professional if you have any questions or concerns.

• Allergic Reactions: There is a possibility of allergic reactions to cephalexin, which can range from mild symptoms like rashes and hives to severe reactions such as facial swelling and anaphylaxis (throat closure). If you have a known allergy to antibiotics, particularly penicillin or other cephalosporins, inform your healthcare provider. Seek immediate medical attention if you experience a rash, hives, red skin, swelling of the lips or tongue, or difficulty breathing after taking cephalexin.

• C. difficile Infection Risk: The use of antibiotics, including cephalexin, increases the risk of Clostridioides difficile (C. diff) infection. This bacterium can proliferate in your gut when normal bacterial balance is disrupted, leading to potentially life-threatening diarrhea.

• Drug-Resistant Bacteria: It is crucial to take cephalexin exactly as prescribed. Misuse or inappropriate duration of use can contribute to the development of drug-resistant bacteria, increasing the risk of severe and difficult-to-treat infections.

• Seizure Risk: Cephalexin may elevate the risk of seizures, particularly at high doses or in individuals with kidney issues where dosage adjustments are not made. Discuss any history of seizures or kidney problems with your healthcare provider to ensure the medication is safe for you.

• Bleeding Risk: There is an increased risk of bleeding, especially in individuals with kidney or liver problems, poor nutrition, or those on anticoagulants (blood thinners). Monitor for signs of excessive bleeding, such as unexplained bruising or blood in urine or stool, and discuss your risk factors with your healthcare provider. If on blood-thinning medication, follow up with your specialist for monitoring and possible dose adjustments.

Contraindications: Cephalexin should not be used if you have a severe allergy to cephalosporin or beta-lactam antibiotics. Consult your healthcare provider if this applies to you before starting the medication.

Common side effects:

• Diarrhea
• Nausea
• Vomiting
• Indigestion
• Stomach pain

Less common but important to monitor:

• Dizziness
• Fatigue
• Headache
• Confusion
• Joint pain
• Yeast infections

Serious side effects:

• Severe allergic reactions
• Severe intestinal condition (C. difficile infection)

Interactions with high risk of serious adverse effects and should be avoided:

• Dofetilide