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This document outlines crucial safety and warning information regarding the use of nimodipine (Nymalize). It is important to carefully consider these details for safe usage. If you have any concerns, please consult your healthcare provider.

• Administration Method: Nimodipine (Nymalize) must be administered orally or through a feeding tube. Under no circumstances should it be injected, as accidental intravenous injection can lead to severe, potentially life-threatening side effects, including significant drops in blood pressure and slow heart rate.

• Risk of Low Blood Pressure: Nimodipine (Nymalize) may cause a significant decrease in blood pressure, leading to symptoms such as dizziness, fatigue, or lightheadedness. Healthcare providers will monitor your blood pressure closely during your hospital stay, and you should continue to monitor it after discharge. To minimize the risk of falls, rise slowly from sitting or lying positions and use support if needed. If you experience a fall with head injury, seek immediate medical attention. If the symptoms of low blood pressure become severe or are accompanied by other issues like blurry vision or nausea, contact your healthcare provider. Contributing factors to low blood pressure include concurrent use of other blood pressure medications, dehydration, prolonged diarrhea, vomiting, or low salt levels.

• Drug Interactions: It is essential to inform your healthcare team about all medications you are taking, as certain drugs can interact with nimodipine (Nymalize). For example, antibiotics such as clarithromycin and antivirals like ritonavir may increase nimodipine levels, heightening the risk of severe hypotension. Conversely, medications like carbamazepine and phenytoin may reduce its effectiveness. Ensure a thorough medication review with your healthcare provider to avoid adverse interactions.

• Emergency Procedures: In case of an overdose or if you experience severe side effects, seek emergency medical assistance immediately.

This information is intended to guide safe use and prevent complications associated with nimodipine (Nymalize). Always follow your healthcare provider's instructions and report any unusual symptoms or concerns.

When taking this medication, some individuals may experience mild side effects, including dizziness, lightheadedness, flushing, swelling of the ankles or feet, low blood pressure, diarrhea, rash, and stomach irritation. To manage dizziness or lightheadedness, try getting up slowly from sitting or lying down. Most people find these side effects manageable, but if they persist or worsen, consulting your healthcare provider is advisable.

Occasionally, you might encounter headaches, nausea, or a slow heartbeat. These effects are generally mild, but seeking medical advice if they become bothersome is recommended.

While serious side effects are rare, they demand immediate attention. These include fainting, severe abdominal pain, stomach bloating, inability to have a bowel movement for more than three days, severe nausea or vomiting, vision changes, or dangerously low blood pressure, indicated by symptoms like dizziness, lightheadedness, pale skin, or feeling faint. Immediate medical help is crucial for any signs of a severe allergic reaction, such as rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

This summary covers key side effects, but if you notice other effects, contacting your healthcare provider is wise.

When taking nimodipine, it's important to be aware of potential interactions with other medications, as they can influence how nimodipine functions in your body. Certain drugs can hinder the elimination of nimodipine, potentially altering its effectiveness. Medications such as apalutamide, cimetidine, enzalutamide, ivosidenib, lumacaftor, mitotane, azole antifungals (like itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John's wort, and seizure medications (including carbamazepine and phenytoin) may affect nimodipine. Additionally, products that might increase your heart rate or blood pressure, like some cough-and-cold remedies, diet aids, or NSAIDs (such as ibuprofen or naproxen), should be discussed with your pharmacist to ensure safe usage.

There are also specific medications that are generally not recommended to be used with nimodipine, as the interactions can be significant. These include boceprevir, clarithromycin, conivaptan, delavirdine, indinavir, ketoconazole, lopinavir, nefazodone, nelfinavir, posaconazole, ritonavir, saquinavir, telaprevir, telithromycin, and voriconazole. If you're taking any of these, your doctor might consider different treatment options.

Some medications might be prescribed together with nimodipine only when necessary, and if so, your doctor may adjust the dosage or frequency. These include carbamazepine, ceritinib, clopidogrel, cobicistat, dantrolene, dexamethasone, digoxin, epirubicin, fosphenytoin, lacosamide, phenobarbital, phenytoin, rifampin, rifapentine, and St John's wort.

Furthermore, certain drug combinations could increase the risk of side effects but may still be considered the best treatment option. In such cases, the dose or frequency may be modified. This applies to medications like dalfopristin, quinupristin, and valproic acid. Always communicate with your healthcare provider regarding all medications and supplements you are taking to ensure safe and effective treatment with nimodipine.