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It is crucial to use nimodipine (Nymalize) safely and correctly to avoid serious health risks. Below are important safety guidelines and warnings to consider:

• Administration Method: Nimodipine should only be taken orally or through a feeding tube. Never administer it by injection into the veins, as this can lead to potentially fatal complications, including severe heart and blood pressure issues.

• Low Blood Pressure Risk: While using nimodipine, there is a possibility of experiencing significantly lowered blood pressure, which might make you feel dizzy, fatigued, or lightheaded. To mitigate this risk, your healthcare provider will regularly monitor your blood pressure during your hospital stay. After discharge, continue to monitor your blood pressure at home. To prevent falls, rise slowly while supporting yourself. Seek immediate medical attention if you fall and sustain a head injury. If dizziness is persistent or accompanied by symptoms such as blurred vision or nausea, consult your healthcare provider. Factors increasing this risk include concurrent use of other blood pressure-lowering medications, dehydration, prolonged diarrhea or vomiting, and low body salt levels.

• Drug Interactions: Inform your healthcare team about all medications you are currently taking. Some drugs, like certain antibiotics and antivirals (e.g., clarithromycin and ritonavir), can increase nimodipine levels in your body, elevating the risk of severe low blood pressure. Other medications, such as carbamazepine or phenytoin, may decrease nimodipine's effectiveness. Ensure your medical team reviews all your medications to prevent harmful interactions.

By following these guidelines and maintaining open communication with your healthcare provider, you can help ensure the safe and effective use of nimodipine.

Common side effects:

• dizziness
• lightheadedness
• flushing
• swelling of the ankles and feet
• low blood pressure
• diarrhea
• rash
• stomach irritation
• headache
• nausea

Serious side effects:

• dangerously low blood pressure
• fainting
• slow or fast heartbeat
• severe abdominal pain
• stomach bloating
• difficulty having a bowel movement for more than three days
• severe nausea or vomiting
• vision changes
• very serious allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Boceprevir
• Clarithromycin
• Conivaptan
• Delavirdine
• Indinavir
• Ketoconazole
• Lopinavir
• Nefazodone
• Nelfinavir
• Posaconazole
• Ritonavir
• Saquinavir
• Telaprevir
• Telithromycin
• Voriconazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Carbamazepine
• Ceritinib
• Clopidogrel
• Cobicistat
• Dantrolene
• Dexamethasone
• Digoxin
• Epirubicin
• Fosphenytoin
• Lacosamide
• Phenobarbital
• Phenytoin
• Rifampin
• Rifapentine
• St John's Wort

Interactions with low risk that usually do not require a change in therapy:

• Dalfopristin
• Quinupristin
• Valproic Acid