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Before using this medication, it is crucial to understand the associated safety information and potential risks. Please review the details below and discuss any concerns with your healthcare provider.

• Low Blood Pressure Risk: Amlodipine (Norvasc) may significantly lower your blood pressure, leading to dizziness, fatigue, or lightheadedness. This is more likely to occur when beginning treatment or increasing the dosage. Individuals with a history of aortic stenosis (narrowed heart valves) are at a higher risk. If you experience severe dizziness, sit down slowly and securely. Contact your healthcare provider, as a dosage adjustment may be necessary. Seek immediate medical attention if you fall and sustain a head injury.

• Heart Attack and Chest Pain: Some individuals may experience worsening chest pain or a heart attack while on amlodipine (Norvasc), especially when starting the medication or increasing the dose. The risk is elevated for those with coronary artery disease (CAD). If you experience symptoms such as dizziness, anxiety, chest pain, chest pressure, heartburn, difficulty breathing, nausea, or vomiting, seek emergency medical help immediately.

There are no specific contraindications listed for this medication. Always consult with your healthcare provider for personalized advice and guidance based on your medical history and current health status.

When taking Norvasc (amlodipine), it's important to be aware of potential interactions with other medications and substances that can affect its effectiveness or increase the risk of side effects. Here are some notable interactions:

Cholesterol-Lowering Medications: Combining amlodipine with Simvastatin can raise simvastatin levels in the blood, increasing the risk of muscle-related side effects. To minimize this risk, the daily dose of simvastatin should not exceed 20 mg when taken with amlodipine.

Immunosuppressants: Amlodipine may elevate blood levels of immunosuppressant drugs like Cyclosporine and Tacrolimus. This can lead to increased side effects, including kidney problems. Regular monitoring of drug levels and appropriate dose adjustments are recommended when these medications are used together.

Erectile Dysfunction Medications: Medications such as Sildenafil, used to treat erectile dysfunction, can lower blood pressure. When combined with amlodipine, there is a risk of excessive blood pressure reduction, leading to symptoms like dizziness or fainting. It's advisable to consult a healthcare provider before using these medications concurrently.

Antifungal Medications: Certain antifungal drugs, including Ketoconazole and Itraconazole, can increase amlodipine levels in the blood by inhibiting its metabolism. This may enhance the blood pressure-lowering effect of amlodipine, potentially causing hypotension. Monitoring for symptoms like dizziness or lightheadedness is important when these medications are taken together.

Rifampin: Rifampin, an antibiotic used to treat tuberculosis, can decrease amlodipine levels in the blood by inducing its metabolism. This may reduce the effectiveness of amlodipine in controlling blood pressure. Close monitoring and possible dose adjustments may be necessary when these drugs are co-administered.

Grapefruit Juice: Consuming grapefruit juice can slightly increase amlodipine levels in the blood. While the clinical significance of this interaction is uncertain, it's advisable to monitor for any unusual side effects if grapefruit juice is consumed regularly.

Always inform your healthcare provider about all medications, supplements, and herbal products you are taking to ensure safe and effective use of amlodipine.