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The following safety information outlines important considerations regarding the use of Orencia (abatacept). Please study these details thoroughly and consult your healthcare provider with any questions or concerns.

• Increased Risk of Infections: Orencia (abatacept) can impair your body’s ability to combat infections, leading to a heightened risk of bacterial, viral, or fungal infections. This is particularly true for individuals currently or recently on other immune-suppressing medications. There is also a potential for reactivation of dormant viruses, such as tuberculosis (TB) or hepatitis B. If you develop signs of an infection like fever, cough, difficulty breathing, or weakness, you may need to pause Orencia (abatacept) treatment. Inform your healthcare provider immediately if you experience these symptoms.

• Severe Allergic Reactions: Usage of Orencia (abatacept) can result in severe allergic responses, possibly leading to life-threatening conditions like facial swelling, shock, or anaphylaxis. If you encounter symptoms such as dizziness, a choking sensation, nausea, or swelling of the eyes, lips, or tongue, seek medical help immediately.

• Vaccination Considerations: There is limited data on how Orencia (abatacept) affects your body's response to vaccines, especially live vaccines. Ensure all vaccinations are up-to-date before starting Orencia (abatacept). Discuss with your healthcare provider before receiving any vaccines during the treatment. Avoid live vaccines while on Orencia (abatacept) and for at least three months after the final dose, as there is a risk of illness from these vaccines.

• Breathing Issues: In clinical studies, adults with chronic obstructive pulmonary disease (COPD) treated with Orencia (abatacept) experienced increased COPD-related side effects. Monitor for worsening symptoms such as shortness of breath or cough, and inform your healthcare provider if these symptoms intensify.

• False High Blood Sugar Readings: The intravenous form of Orencia (abatacept) contains maltose, which can lead to falsely elevated blood sugar readings if you use certain glucose monitors that detect sugar using GDH-PQQ. This may increase the risk of hypoglycemia if insulin is administered based on these readings. Verify with your pharmacist or the glucose monitor manufacturer whether your device is compatible with maltose-containing products.

There are no known contraindications for Orencia (abatacept). Always consult your healthcare provider for personalized medical advice.

When taking this medication, some individuals may experience common side effects such as headaches, sore throat, runny nose, or other cold-like symptoms. These effects are typically mild and include dizziness, cough, back pain, high blood pressure, upset stomach, and symptoms of a urinary tract infection. Pain, irritation, or swelling at the injection site may also occur. If these symptoms persist or worsen, it's advisable to consult a healthcare provider.

While many users do not encounter serious side effects, it is important to be aware of more severe reactions. This medication can weaken the immune system, increasing the risk of serious infections, which are rare but can be life-threatening. Symptoms of such infections include persistent sore throat, fever, chills, or difficulty breathing. Additionally, there is a rare risk of cancer, with symptoms such as unusual lumps, skin changes, swollen glands, night sweats, or unexplained weight loss.

In very rare cases, individuals might experience a severe allergic reaction, which requires immediate medical attention. Symptoms include rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, and trouble breathing. If you notice any side effects not mentioned here or have concerns, it's important to contact a healthcare professional promptly.