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Oxaprozin, a nonsteroidal anti-inflammatory drug (NSAID), has associated risks and precautions that should be carefully considered. The following points outline critical safety information to ensure its safe use:

• Heart Risks: Oxaprozin may increase the likelihood of blood clots, which can lead to heart attacks or strokes, particularly with prolonged use or higher doses. Older adults and those with pre-existing heart conditions are at greater risk. Avoid using oxaprozin immediately before or after heart surgery (CABG). Seek immediate medical assistance if you experience symptoms such as chest pain, shortness of breath, or sudden weakness on one side of the body.

• Gastrointestinal Bleeding: This medication can cause serious stomach or intestinal bleeding, potentially without any warning signs. The risk is higher in older adults, those with a history of ulcers or bleeding problems, and those consuming alcohol or smoking. Discontinue use and contact a healthcare provider immediately if you experience persistent abdominal pain, bloody or dark stools, or vomit that resembles coffee grounds.

• Blood Pressure and Heart Failure: Oxaprozin may cause fluid retention, elevating blood pressure or increasing the risk of heart failure. Individuals with a history of heart conditions or those on blood pressure medications should consult their healthcare provider before starting this drug. Notify your provider if you experience fainting, chest pain during physical activity, or an irregular heartbeat.

• Kidney Health: The use of oxaprozin can lead to kidney issues, especially in older adults or those with diabetes, dehydration, or existing kidney problems. Regular monitoring of kidney function through blood tests may be required. Contact your healthcare provider if you notice changes in urination, fatigue, dry or itchy skin, or muscle cramps.

• Liver Concerns: Though rare, oxaprozin can cause severe liver problems. Immediate medical attention is necessary if you observe symptoms like stomach swelling, jaundice, dark urine, or confusion.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur. Those with allergies to aspirin or other NSAIDs should exercise caution. Seek emergency care if you develop hives, swelling of the face or tongue, or difficulty breathing.

• Pregnancy and Breastfeeding: Oxaprozin is not recommended for use during pregnancy, especially in the latter half, due to potential harm to the unborn baby. Consult your healthcare provider to weigh the risks and benefits if you are pregnant or breastfeeding.

• Contraindications: Do not use oxaprozin if you have a history of asthma or allergic reactions to aspirin or other NSAIDs, or if you have undergone coronary artery bypass graft surgery (CABG).

Always discuss with your healthcare provider to fully understand the risks and benefits of oxaprozin and to ensure it is safe for your individual health needs.

When taking this medication, you may experience some common side effects, such as an upset stomach, constipation, diarrhea, nausea, vomiting, gas, heartburn, dizziness, or headache. These are generally mild, but if they persist or become bothersome, it's advisable to consult your healthcare provider.

Occasionally, the medication may also lead to an increase in blood pressure, so monitoring it regularly is important. More uncommon side effects include vision or hearing changes (like ringing in the ears), mood alterations, and signs of kidney trouble such as changes in urination. If you notice easy bruising or bleeding, symptoms of heart failure such as swollen ankles, unusual tiredness, or sudden weight gain, it’s important to seek medical advice promptly.

Though rare, severe side effects require immediate medical attention. These include symptoms of liver damage, such as persistent nausea or vomiting, loss of appetite, dark urine, severe stomach pain, or yellowing of the eyes or skin. Other serious concerns include stomach bleeding, heart attack, stroke, or heart failure symptoms. Additionally, kidney issues might manifest as tiredness, skin changes, reduced appetite, or unusual urine output.

Furthermore, while very rare, serious allergic reactions can occur, marked by fever, swollen lymph nodes, severe rash, itching or swelling (especially of the face, tongue, or throat), dizziness, or breathing difficulties. Serious skin reactions, such as reddening, blisters, or rash, also necessitate urgent medical care. If you experience any side effects not mentioned here, contact your healthcare provider for advice.

Oxaprozin may interact with various medications and it's important to inform your healthcare provider about any other drugs or supplements you are taking. Some drugs should not be used with Oxaprozin, such as Ketorolac, unless directed by your doctor. In some cases, Oxaprozin can be combined with other medications, but your doctor might need to adjust the dosages. These medications include blood thinners like Clopidogrel and Warfarin, certain diuretics, and various pain relievers such as Ibuprofen and Aspirin.

Taking Oxaprozin with these medicines may increase your risk of side effects, including bleeding. If you're prescribed low-dose aspirin for heart protection, continue taking it unless advised otherwise by your doctor. Notify your healthcare provider and lab personnel that you're using Oxaprozin, as it may affect some lab test results. Always check with your doctor or pharmacist if you have questions about drug interactions or potential side effects.