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When using nonsteroidal anti-inflammatory drugs (NSAIDs) like naproxen, it's important to be aware of certain risks and precautions. Here is a summary of key safety information:

• Risk of Heart Attack or Stroke: Naproxen may increase the risk of a heart attack or stroke, which can occur at any time during use, especially with long-term consumption. This risk is heightened for older adults or those with existing heart disease or factors that increase heart disease risk, such as smoking, family history, high blood pressure, or diabetes. Avoid using naproxen just before or after heart bypass surgery (CABG).

• Gastrointestinal Bleeding: The medication can rarely cause serious, and sometimes fatal, bleeding in the stomach or intestines. This can happen unexpectedly and at any time while taking the drug. Older adults are particularly susceptible to this risk.

• Immediate Medical Attention: Discontinue use and seek medical help immediately if you experience severe stomach or abdominal pain, black or tarry stools, vomit resembling coffee grounds, chest pain, pain in the jaw or left arm, shortness of breath, unusual sweating, confusion, weakness on one side of the body, difficulty speaking, or sudden changes in vision.

• Consultation: Discuss with your healthcare provider or pharmacist to thoroughly understand the benefits and potential risks of using naproxen.

This information is crucial for making informed decisions about naproxen and ensuring its safe usage. Always follow the guidance of your healthcare professional.

You might experience mild side effects such as an upset stomach, nausea, heartburn, headache, drowsiness, or dizziness, which are usually not serious. If these persist or worsen, it is important to inform your healthcare provider.

Monitoring your blood pressure is important, as this medication can cause an increase. Report any high readings to your healthcare provider. Serious side effects are uncommon, but contact your healthcare provider immediately if you experience easy bruising or bleeding, difficulty or pain when swallowing, hearing changes like ringing in the ears, mental or mood alterations, signs of kidney issues such as changes in urine output, vision changes, or symptoms of heart failure like swelling in the ankles or feet, unusual tiredness, or sudden weight gain.

In rare cases, this drug can lead to severe liver disease. Seek urgent medical attention if you notice symptoms such as persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, or dark urine. Additionally, a severe allergic reaction is rare but requires immediate medical help if you experience symptoms like fever, swollen lymph nodes, rash, itching or swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing.

This summary does not cover all possible side effects. If you observe any effects that concern you, please reach out to your healthcare provider.

Be cautious when using this medication with certain other drugs, as interactions may occur. These include Aliskiren, ACE inhibitors (like Captopril and Lisinopril), angiotensin II receptor blockers (such as Losartan and Valsartan), Cidofovir, corticosteroids (like Prednisone), Lithium, and diuretics like Furosemide. Taking this medication alongside others that increase bleeding risk, such as anti-platelet drugs like Clopidogrel and anticoagulants like Dabigatran, Enoxaparin, or Warfarin, may heighten the chance of bleeding.

It's important to check both prescription and over-the-counter medication labels carefully for pain relievers or fever reducers, such as Aspirin and NSAIDs like Celecoxib, Ibuprofen, or Ketorolac, as they are similar to naproxen and could raise the risk of side effects. If you've been advised by your doctor to take low-dose aspirin (81-162 mg daily) to prevent heart attack or stroke, continue doing so unless instructed otherwise by your doctor. Be aware that daily use of naproxen can reduce aspirin's effectiveness in preventing heart attack or stroke. Discuss with your doctor the potential risks and benefits, and inquire about alternative medications for pain or fever management.

Also, note that this medication might affect certain laboratory tests, leading to inaccurate results. Ensure all laboratory personnel and healthcare providers are informed that you are taking this medication.