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Naproxen Safety and Warnings

When considering the use of naproxen, it is crucial to be aware of potential risks and necessary precautions to ensure safe treatment. Below are important safety warnings and instructions to discuss with your healthcare provider:

• Heart Attack and Stroke Risks: Naproxen may increase the risk of heart attack or stroke, especially with prolonged use or in individuals with pre-existing heart conditions. This risk is heightened in older adults and those with risk factors such as smoking or high blood pressure. Avoid using naproxen immediately before or after heart bypass surgery. Seek immediate medical help if you experience chest pain, shortness of breath, weakness on one side, or difficulty speaking.

• Stomach and Intestinal Bleeding: This medication can cause serious bleeding in the stomach or intestines, sometimes without warning. Older adults, those with a history of stomach issues, or individuals on other medications increasing bleeding risk are more susceptible. Immediately seek medical attention if you experience persistent stomach pain, black or tarry stools, or vomit resembling coffee grounds.

• Blood Pressure and Heart Failure: Naproxen might cause fluid retention, leading to elevated blood pressure or heart failure. Inform your healthcare provider if you have heart issues or are on blood pressure medications. Monitor for symptoms such as unexplained fainting, chest pain during activity, or irregular heartbeat.

• Kidney Damage: The use of naproxen can lead to kidney issues, particularly in older adults or those with diabetes. Your healthcare professional may conduct tests to monitor kidney function. Contact them if you notice changes in urination, fatigue, dry or itchy skin, or muscle cramps.

• Liver Problems: Though rare, liver damage is possible with naproxen use. Discontinue use and seek medical attention if you notice signs such as abdominal swelling, jaundice, changes in stool color, or dark urine.

• Severe Allergic Reactions: Allergic reactions, including anaphylaxis, can occur. Avoid this medication if you have a known allergy to aspirin or NSAIDs. Get urgent medical help if you experience hives, rash, facial swelling, or breathing difficulties.

• Pregnancy and Breastfeeding: Naproxen can harm an unborn baby, especially in the later stages of pregnancy, and may also affect breastfeeding. If you are pregnant or breastfeeding, consult your healthcare provider to evaluate risks and explore safer alternatives.

• Contraindications: Naproxen should not be used in individuals with a history of asthma, hives, or allergic reactions to aspirin or other NSAIDs, or those undergoing coronary artery bypass graft surgery.

Discuss the benefits and risks of naproxen with your healthcare provider to ensure it is safe for your specific health needs.

Common side effects:

• upset stomach
• nausea
• heartburn
• headache
• drowsiness
• dizziness
• itchy skin
• bruising
• ringing in the ears
• swelling
• stomach pain
• constipation
• indigestion
• diarrhea
• spinning sensation

Less common but important to monitor:

• increase in blood pressure
• sweating
• mouth sores
• unusual thirst

Serious side effects:

• stomach bleeding
• vomiting blood
• severe stomach pain
• heart attack
• stroke
• chest pain
• slurred speech
• heart failure
• dangerously high blood pressure
• liver problems
• kidney issues
• difficulty breathing
• yellowing of the skin
• changes in urination
• allergic reactions
• hives
• rash
• swelling of the lips or tongue

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren
• ACE inhibitors (such as Captopril, Lisinopril)
• Angiotensin II receptor blockers (such as Losartan, Valsartan)
• Diuretics (such as Furosemide)
• Corticosteroids (such as Prednisone)
• Lithium
• Anti-platelet drugs (such as Clopidogrel)
• Blood thinners (such as Dabigatran, Enoxaparin, Warfarin)
• NSAIDs (such as Celecoxib, Ibuprofen, ketorolac)
• Aspirin