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This medication is generally well-tolerated, but like all medicines, it can cause side effects in some people. The most common side effects include darkening of the stools or tongue, which are benign and typically resolve once the medication is stopped. While the majority of users do not experience serious side effects, it is important to be aware of potential reactions.

In rare cases, the medication may lead to persistent vomiting or diarrhea, which can cause dehydration. Signs of dehydration include reduced urination, dry mouth or increased thirst, a fast heartbeat, or dizziness. If these occur, it is important to seek medical advice promptly.

Additionally, some individuals may experience serious side effects such as ringing in the ears or hearing loss. This medication can also rarely cause severe bleeding from the stomach or intestines, which is potentially fatal. Symptoms to watch for include persistent stomach pain, vomit resembling coffee grounds, or black, tarry, or bloody stools. If these symptoms occur, discontinue use and consult a healthcare professional immediately.

Though a very serious allergic reaction is uncommon, you should seek immediate medical attention if you notice symptoms such as rash, swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you encounter any side effects not listed here, contact your healthcare provider for guidance.

This medication can interact with several other drugs, including valproic acid, carbonic anhydrase inhibitors like acetazolamide, corticosteroids such as prednisone, dichlorphenamide, and methotrexate. Additionally, it may increase the risk of bleeding if taken with other medications that have similar effects, such as anti-platelet agents like clopidogrel and anticoagulants including dabigatran, enoxaparin, and warfarin.

Be cautious with over-the-counter and prescription medications, as many contain NSAIDs like aspirin, ibuprofen, or naproxen, which are similar to this drug and may heighten side effects if used together. However, if you're on low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention, continue as advised by your doctor unless directed otherwise.

This medication could also affect certain medical or laboratory tests, such as intestinal x-rays with contrast dye, potentially leading to inaccurate results. It's important to inform your healthcare providers and lab personnel that you are using this medication.