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This document provides crucial safety and warning information regarding the use of promethazine. It contains important details about potential risks, precautions, and emergency measures. Review this information carefully and consult your healthcare provider if you have any questions or concerns.

• Respiratory Risks:

  • Promethazine can cause severe respiratory depression, especially in children under 2 years old and individuals with pre-existing breathing problems like COPD or asthma. Avoid use in children under 2 years and consult your doctor if taking other medications affecting breathing.
  • Seek immediate medical attention if you or your child experiences slow or shallow breathing.

• Injection Risks:

  • Administer promethazine by intramuscular injection to avoid serious tissue injury, such as gangrene. Do not inject into an artery or under the skin. If you experience burning, pain, redness, or swelling at the injection site, contact your healthcare provider immediately.

• Sedation and Impaired Function:

  • Promethazine can cause excessive drowsiness, especially when combined with alcohol, opioids, or other sedatives. Avoid driving or operating machinery after taking this medication. Seek medical help if you experience confusion, dizziness, or slurred speech.

• Exacerbation of Medical Conditions:

  • Promethazine may worsen conditions such as glaucoma, heart problems, enlarged prostate, bladder issues, or liver disease. Discuss all existing health problems with your healthcare provider before starting treatment.

• Seizure Risk:

  • If you have a history of seizures or are taking medications that lower the seizure threshold, promethazine may increase seizure frequency. Consult your doctor if you fall into this risk category.

• Infection Risk:

  • Promethazine can lower white blood cell counts, increasing infection risk, especially during cancer treatment. Notify your healthcare team if you develop symptoms like fever or chills.

• Neuroleptic Malignant Syndrome:

  • This rare but serious condition may occur, especially if taking antipsychotic medications. Symptoms include high fever, rapid heartbeat, and muscle stiffness. Seek medical attention immediately if these occur.

• Involuntary Movements:

  • Promethazine may cause involuntary muscle movements, particularly in children who are sick and dehydrated or those taking MAOIs. Report any unusual muscle movements to a healthcare provider promptly.

Contraindications:

• Do not use promethazine in children under 2 years, individuals in a coma, for lower respiratory issues like asthma, if allergic to phenothiazines, or if injection is required into an artery or under the skin.

This information is intended to guide safe usage of promethazine. Always consult your healthcare provider for personalized medical advice.

When taking this medication, some individuals may experience common side effects such as drowsiness, dizziness, dry mouth, blurred vision, or confusion. These are typically mild and can often be managed by simple measures like staying hydrated or using sugarless gum for dry mouth. If these effects persist or worsen, it's important to consult with a healthcare provider for guidance.

In some cases, other side effects such as burning sensations, pain, rash, or swelling may occur. While these are generally not severe, it's advisable to contact a healthcare professional if you notice them.

More serious side effects, although rare, demand immediate medical attention. These include symptoms like tremors, nausea, vomiting, uncontrollable body movements, and changes in heart rate. Additionally, severe side effects like a slow or irregular heartbeat, fainting, and neuroleptic malignant syndrome—characterized by fever, muscle stiffness, and severe confusion—are critical and require urgent care.

Allergic reactions to this medication are rare but serious. Symptoms such as rash, itching or swelling, severe dizziness, or trouble breathing warrant prompt medical assistance. Always be vigilant for any unusual symptoms and seek professional advice when needed.

When taking this medication, it’s important to be aware of potential interactions with other drugs or substances. This medication can interact with skin-applied antihistamines like diphenhydramine creams or sprays, and metoclopramide. Using it alongside other products that cause drowsiness or breathing issues, such as opioid painkillers (e.g., codeine, hydrocodone), alcohol, cannabis, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), and muscle relaxants (e.g., carisoprodol, cyclobenzaprine), can increase the risk of severe side effects, including significant drowsiness or breathing difficulties. It’s crucial to inform your healthcare provider if you are using any of these substances.

Additionally, be cautious with other medications such as Bepridil, Bromopride, Calcium Oxybate, and others listed, as combining these with this medication is generally not recommended. If your doctor prescribes both, they may adjust dosages or usage frequency to mitigate risks.

Also, be aware that this medication can interfere with certain lab tests, potentially leading to false results. Make sure to inform lab staff and all your healthcare providers that you are using this drug.

Always consult with your doctor or pharmacist about all medications you are taking, including over-the-counter drugs, vitamins, and supplements, to ensure safe usage and avoid interactions.