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The following safety information outlines the potential risks and necessary precautions associated with the use of pancrelipase (Creon). It is important to review these details carefully and discuss any concerns with your healthcare provider.

• Colon Scarring (Fibrosing Colonopathy): Pancrelipase (Creon) can lead to serious colon scarring, particularly when used in high doses or over prolonged periods. This condition has been most frequently observed in children with cystic fibrosis. It is crucial to adhere strictly to your healthcare provider's dosage and duration recommendations. High doses and long-term use, especially in children with cystic fibrosis, increase this risk.

• Mouth Irritation: To avoid mouth irritation, swallow pancrelipase (Creon) whole. Do not chew, crush, or retain it in your mouth. Swallow it immediately with water or juice to ensure complete ingestion. Alternatively, you may sprinkle the capsule contents on applesauce, consume it immediately, and follow with water or juice.

• Elevated Uric Acid Levels: This medication may increase uric acid levels, potentially leading to gout. If you have a history of gout, kidney issues, or elevated uric acid, consult your healthcare provider before using pancrelipase (Creon).

• Infection Risk: While extremely rare, there exists a slight possibility of viral infection due to the porcine origin of pancrelipase (Creon). Despite stringent manufacturing processes to eliminate viruses, if this potential concern affects you, please discuss it with your healthcare provider.

• Allergic Reactions: As pancrelipase (Creon) is derived from pork, individuals with pork allergies should consult their healthcare provider to determine the suitability of this medication. Seek immediate medical attention if you experience difficulty breathing, a rash, or facial/throat swelling as these may be signs of an allergic reaction.

Please be aware that there are no contraindications listed for pancrelipase (Creon). Always follow medical advice and report any adverse effects to your healthcare provider promptly.

When taking this medication, you may experience some common and mild side effects. These include diarrhea, constipation, headache, abdominal pain, cramps, bloating, gas, cough, nausea, vomiting, dizziness, and changes in your blood sugar levels or bowel movements. While these side effects are usually not serious, it's important to monitor them and consult your healthcare provider if they persist or worsen.

In some cases, more serious side effects can occur. These include severe constipation, intense stomach or abdominal discomfort, frequent or painful urination, and joint pain. If you experience any of these, contact your healthcare provider immediately.

Allergic reactions to this medication are rare, but they can be very serious. Seek medical attention right away if you notice symptoms such as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, or trouble breathing. Always keep in mind that while many individuals do not experience severe side effects, staying informed and vigilant about your health is crucial.