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Doravirine, marketed as Pifeltro, is an antiretroviral medication used in the treatment of HIV. It is prescribed for adults and children weighing at least 77 pounds, and it is particularly suitable for patients who have never taken HIV antiretrovirals or those with a viral load under 50 copies/mL. Doravirine must be used alongside other HIV medications. This drug belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and works by inhibiting the reverse transcriptase enzyme, thereby preventing the HIV virus from replicating and spreading in the body. By reducing the amount of HIV in the body, Doravirine helps enhance the immune system's function, which lowers the risk of HIV-related complications such as infections and cancer, and improves overall quality of life. Although not a cure for HIV, consistent use of Doravirine as directed by a healthcare professional, along with other prescribed HIV medications, is essential. To prevent the transmission of HIV, it is crucial to follow your doctor's advice on using effective barrier methods during sexual activity and avoid sharing personal items that may contact blood or bodily fluids. Common side effects of Doravirine include dizziness, nausea, and headaches. Always consult your doctor, nurse, or pharmacist for advice tailored to your health needs.