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When taking Epzicom, it is crucial to be aware of the following safety information and potential risks associated with the medication. Review these points carefully and consult your healthcare provider if you have any questions or concerns.

• Severe Allergic Reaction: Some individuals may experience serious or even life-threatening allergic reactions to Epzicom, typically within the first six weeks of starting the medication. A genetic test will be conducted by your healthcare provider to assess your risk before beginning treatment. If you test positive for the HLA B5701 gene or have a history of allergic reactions to Epzicom, you should not take this medication. If you experience symptoms such as rash, swelling, difficulty breathing, or any combination of symptoms from two or more groups, stop taking Epzicom and seek immediate medical assistance.

• Worsening of Hepatitis B: Discontinuing Epzicom can lead to a severe exacerbation of hepatitis B symptoms. Do not stop taking the medication unless your healthcare provider advises you to do so. If instructed to stop, regular monitoring of liver function and hepatitis B virus levels through blood tests is necessary.

• Liver Problems: Although rare, Epzicom and similar medications (NRTIs) can cause severe liver issues, such as lactic acidosis with hepatic steatosis. Women, those with obesity, or a history of liver problems may be at higher risk. Symptoms include loss of appetite, stomach pain, muscle pain, shallow breathing, severe fatigue, and sudden weakness. Discontinue Epzicom and seek emergency medical care if you experience these symptoms.

• Immune Reconstitution Syndrome: As your immune system recovers with HIV treatment, it might cause inflammation due to the clearance of existing infections. Your healthcare provider may screen for these infections before starting Epzicom if it's your first time using HIV medications. Contact your provider if you develop fever, breathing difficulties, or sudden health changes after starting the medication.

• Heart Attack: There is a potential increased risk of heart attack when taking Epzicom, particularly for those with high blood pressure, high cholesterol, or diabetes. Discuss your complete medical history and all current medications with your HIV provider to assess your risk.

In case of any symptoms or concerns, it is imperative to contact your healthcare provider for guidance and support. Always inform them about any past allergic reactions to ensure the safe use of this medication.

Common side effects:

• Headache
• Nausea
• Diarrhea
• Dizziness
• Tiredness
• Trouble sleeping

Less common but important to monitor:

• Reactivation of previous infections
• Overactive immune response
• Unexplained weight loss
• Severe tiredness
• Persistent muscle pain
• Severe headaches
• Joint pain
• Numbness
• Vision changes
• Signs of infection
• Symptoms of an overactive thyroid

Serious side effects:

• Signs of liver problems
• Lactic acidosis
• Pancreatitis

Interactions with high risk of serious adverse effects and should be avoided:

• Emtricitabine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Orlistat

Interactions with low risk that usually do not require a change in therapy:

• Sorbitol