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It is crucial to be informed about the safety and warning details associated with Prestalia (perindopril / amlodipine) to ensure safe usage. Below is a summary of important precautions and potential risks:

• Harm to Unborn Baby: This medication can cause severe harm, or even death, to an unborn baby. It is essential to use effective birth control while taking Prestalia. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, discontinue use immediately and contact your healthcare provider.

• Swelling (Angioedema): You may experience swelling around the eyes, lips, face, throat, hands, or feet. This can occur at any time during treatment. If you notice these symptoms, seek medical attention promptly. Increased risk is noted in Black individuals and those taking mTOR inhibitors (e.g., everolimus) or neprilysin inhibitors (e.g., sacubitril/valsartan).

• Low Blood Pressure: Prestalia can lower blood pressure, leading to lightheadedness or dizziness, especially if dehydrated or if you have low salt levels. Be cautious when starting treatment or changing doses, and if you are taking other blood pressure-lowering medications.

• High Potassium Levels (Hyperkalemia): This medication may increase potassium in your body, potentially leading to heart issues. Routine blood tests are necessary to monitor potassium levels. Report symptoms like muscle weakness, chest pain, irregular heartbeat, or nausea to your provider immediately.

• Worsening Kidney Problems: Rarely, Prestalia can lead to kidney failure. Regular blood tests are advised to monitor kidney function. Notify your provider if you experience reduced urination or dark urine despite being hydrated.

• Liver Damage: Although uncommon, Prestalia can cause liver damage. Liver function should be tested before and during treatment. Seek medical advice if you notice yellowing skin or eyes, dark urine, or abdominal pain and swelling.

Contraindications:

• Do not use Prestalia if you are taking aliskiren and have diabetes.
• Avoid combining Prestalia with neprilysin inhibitors like Entresto, especially within 36 hours of Entresto use.

These precautions are essential for your safety while using Prestalia. Always consult your healthcare provider if you have any concerns or questions regarding your treatment.

When starting this medication, some individuals might experience mild side effects such as dizziness, lightheadedness, swelling of the legs or ankles, dry cough, headache, or nausea. These effects are typically manageable, and adjusting slowly from sitting or lying positions can help reduce dizziness. If these symptoms persist or worsen, it is advisable to reach out to your healthcare provider for guidance.

In rare cases, more serious side effects may occur, requiring immediate medical attention. These include fainting, a rapid or irregular heartbeat, symptoms of high potassium levels like muscle weakness, or signs of kidney issues such as changes in urination. Individuals with severe heart disease may experience worsening chest pain or a heart attack, particularly after starting or increasing the dose of this medication. Prompt medical care is crucial if you notice chest, jaw, or left arm pain, unusual sweating, or shortness of breath.

Furthermore, although extremely rare, this medication can lead to serious allergic reactions characterized by rash, severe dizziness, or breathing difficulties. It may also cause potentially fatal liver problems, signaled by persistent nausea or vomiting, loss of appetite, or yellowing of the skin or eyes. Seek urgent medical help if any of these symptoms arise. While most users do not encounter severe issues, staying informed and consulting healthcare providers when needed ensures safe and effective use of the medication.