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This medication carries several important safety considerations and warnings. It is crucial to understand these risks and follow the advice of your healthcare provider to ensure safe use.

• Pregnancy Warning: Taking Lotrel (amlodipine/benazepril) during pregnancy can lead to severe and potentially fatal harm to an unborn child. If you are pregnant, planning to become pregnant, or suspect you might be pregnant, consult your healthcare provider immediately. Effective birth control is recommended while on this medication.

• Angioedema Risk: Lotrel, which contains an ACE inhibitor, may cause angioedema, a serious condition characterized by swelling of the face, throat, and tongue, potentially leading to breathing difficulties. This risk is higher in Black individuals and those with a history of angioedema. Seek urgent medical attention if you experience swelling, stomach pain, or breathing problems, and discontinue the medication.

• Low Blood Pressure: This medication may cause a significant drop in blood pressure, leading to dizziness, fatigue, or lightheadedness, particularly when starting treatment or increasing the dose. Stay hydrated and contact your healthcare provider if you experience these symptoms. Immediate medical help is advised if you fall and sustain a head injury.

• Heart Concerns: There is a risk of worsening chest pain or heart attack when initiating or increasing the dose of Lotrel, especially in individuals with coronary artery disease. Prompt medical assistance is necessary if you encounter chest pain, pressure, heartburn, dizziness, or difficulty breathing.

• Kidney Function: Lotrel can impair kidney function, particularly in those with heart failure, existing kidney issues, or while taking medications that affect the kidneys. Regular kidney function tests may be recommended. Notify your provider if you experience reduced urine output.

• High Potassium Levels: This medication can elevate blood potassium levels, posing a risk even to individuals with healthy kidneys. The risk increases if combined with other potassium-raising drugs. Symptoms like nausea, muscle weakness, or irregular heartbeat should be reported to your healthcare provider immediately.

• Liver Issues: Rare instances of liver problems have been reported. Seek medical attention if you notice symptoms such as yellowing skin or eyes, nausea, vomiting, or dark urine. Your provider may advise discontinuation of the medication to prevent further liver damage.

Contraindications:

• Avoid using Lotrel if you have diabetes and are taking aliskiren (Tekturna).
• Do not use if you have a history of angioedema.
• Avoid concurrent use with neprilysin inhibitors, such as sacubitril/valsartan (Entresto), or within 36 hours of taking these medications.

Please consult your healthcare provider for further guidance and to address any concerns regarding the use of this medication.

When taking this medication, some individuals may experience common side effects such as dizziness, lightheadedness, dry cough, headache, or swelling in the hands, ankles, or feet. These effects are generally mild and may diminish as your body adjusts to the medication. To minimize dizziness or lightheadedness, it is advisable to rise slowly from sitting or lying down.

In addition to these common effects, some users might notice skin reactions like rash or flushing, and occasional sleepiness. If any of these symptoms persist or worsen, consulting a healthcare provider is recommended.

More serious side effects are rare but require immediate medical attention. These include severe allergic reactions characterized by rash, swelling of the face, tongue, or throat, and difficulty breathing. Angioedema, marked by significant swelling of the face, extremities, or throat, is a serious concern. Symptoms of a heart attack, such as chest pain or a tight feeling in the neck, arms, or back, and symptoms of kidney problems or high blood potassium levels, like muscle weakness or an abnormal heartbeat, also warrant urgent care.

Additionally, signs of severe liver damage, such as persistent nausea, abdominal pain, yellowing of the skin or eyes, and dark urine, should prompt immediate medical attention. It's important to be aware of these potential side effects and seek medical help if you experience any severe symptoms.

When using Lotrel (amlodipine/benazepril), it's important to be aware of potential drug interactions. Certain medications can interact with Lotrel, so always inform your doctor and pharmacist about all other medications or supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Some medications, such as Aliskiren and Sacubitril, should not be used with Lotrel. Your doctor might choose alternative treatments if these are required. Additionally, Lotrel is usually not recommended with certain drugs, but in some situations, your doctor might adjust the dosage or frequency if both medications are necessary. These include drugs like Everolimus, Sirolimus, Lithium, ARBs (such as Losartan or Valsartan), and birth control pills containing drospirenone.

Other medications, including NSAIDs like Ibuprofen and Naproxen, might increase the risk of side effects when used with Lotrel. Gold injections and medications that can elevate potassium levels, such as certain diuretics and ARBs, may also interact with Lotrel.

Be cautious when using products that can raise your blood pressure, such as cough-and-cold medications, diet aids, or NSAIDs. A serious reaction may occur if you are undergoing desensitization treatments for bee or wasp stings while taking benazepril. Ensure all healthcare providers are aware of your current medication list for safe management.