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This safety information provides critical details regarding the use of lidocaine/prilocaine cream. It is essential to follow your healthcare provider's guidance and to be aware of potential risks, especially if you have specific health conditions or are taking other medications. Below are key points to consider:

• Overdose Risks: Avoid applying lidocaine/prilocaine to large skin areas or longer than advised, as excessive absorption can occur. This is particularly risky for individuals with severe liver disease, potentially leading to severe side effects like seizures or respiratory problems. Older adults or those who are frail may be more susceptible. Always adhere to your healthcare provider's instructions.

• Heart Rate or Rhythm Changes: If you are using heart medications such as amiodarone or sotalol, be aware that lidocaine/prilocaine might amplify these drugs' effects, potentially altering heart rate or rhythm. Inform your provider if you are on such medications to determine if monitoring is necessary.

• Methemoglobinemia Risk: This serious blood condition results in reduced oxygen delivery by red blood cells. Symptoms include blue or gray skin, seizures, or heart rate changes. Those with G6PD deficiency, heart or lung conditions, or using oxidizing agents like benzocaine or dapsone should exercise caution. Seek immediate medical attention if you notice symptoms such as pale skin, headache, rapid heartbeat, breathing difficulties, or dizziness.

• Application Restrictions: Do not apply lidocaine/prilocaine to the middle ear, as studies indicate potential hearing or balance issues. Use only on the skin and as prescribed.

Please discuss any concerns or questions with your healthcare provider to ensure safe use of this medication.

Prilovix Lite is a topical anesthetic cream containing Lidocaine and prilocaine, used to numb the skin before certain medical procedures. While it is applied externally, it's important to be aware of potential interactions with other substances that could affect its safety and effectiveness.

Medications That May Interact with Prilovix Lite:

Certain medications can interact with Prilovix Lite, potentially leading to adverse effects. These include:

• Acetaminophen: Commonly used for pain relief and fever reduction.

• Antibiotics: Such as Dapsone, Nitrofurantoin, aminosalicylic acid, and Sulfasalazine.

• Seizure Medications: Including Phenobarbital, Phenytoin, and Valproic Acid.

• Antimalarial Drugs: Like chloroquine and Primaquine.

• Cancer Treatments: Such as Cyclophosphamide, Flutamide, Hydroxyurea, and ifosfamide.

• Gastrointestinal Medications: Including Metoclopramide.

• Heart Medications: Such as Nitroglycerin.

• Other Local Anesthetics: Like Pramoxine and tetracaine.

• Antimalarial Drugs: Including quinine.

Using Prilovix Lite alongside these medications may increase the risk of a rare but serious blood condition called methemoglobinemia, which affects the blood's ability to carry oxygen. Symptoms can include headache, fatigue, shortness of breath, and a bluish tint to the skin or lips.

Cannabis Use:

The use of cannabis can also interact with Prilovix Lite. Cannabis may decrease the effectiveness of lidocaine, one of the active ingredients in Prilovix Lite, by reducing its concentration in the body. This interaction is more pronounced with chronic inhalation of cannabis. It's advisable to discuss cannabis use with your healthcare provider to ensure safe and effective use of Prilovix Lite.

General Recommendations:

Before using Prilovix Lite, inform your healthcare provider about all medications, supplements, and substances you are currently using. This includes prescription and over-the-counter drugs, herbal products, and recreational substances like cannabis. Your healthcare provider can help you understand potential interactions and determine the safest course of action.

Always follow the prescribed instructions for applying Prilovix Lite, and do not use it on broken or irritated skin unless directed by your healthcare provider. If you experience any unusual symptoms or side effects while using this medication, seek medical attention promptly.