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This safety information provides critical details regarding the use of lidocaine/prilocaine cream. It is essential to follow your healthcare provider's guidance and to be aware of potential risks, especially if you have specific health conditions or are taking other medications. Below are key points to consider:

• Overdose Risks: Avoid applying lidocaine/prilocaine to large skin areas or longer than advised, as excessive absorption can occur. This is particularly risky for individuals with severe liver disease, potentially leading to severe side effects like seizures or respiratory problems. Older adults or those who are frail may be more susceptible. Always adhere to your healthcare provider's instructions.

• Heart Rate or Rhythm Changes: If you are using heart medications such as amiodarone or sotalol, be aware that lidocaine/prilocaine might amplify these drugs' effects, potentially altering heart rate or rhythm. Inform your provider if you are on such medications to determine if monitoring is necessary.

• Methemoglobinemia Risk: This serious blood condition results in reduced oxygen delivery by red blood cells. Symptoms include blue or gray skin, seizures, or heart rate changes. Those with G6PD deficiency, heart or lung conditions, or using oxidizing agents like benzocaine or dapsone should exercise caution. Seek immediate medical attention if you notice symptoms such as pale skin, headache, rapid heartbeat, breathing difficulties, or dizziness.

• Application Restrictions: Do not apply lidocaine/prilocaine to the middle ear, as studies indicate potential hearing or balance issues. Use only on the skin and as prescribed.

Please discuss any concerns or questions with your healthcare provider to ensure safe use of this medication.

When using this medication, some individuals may encounter common side effects, which are generally mild. These include skin paleness, redness, burning sensations, swelling, changes in temperature sensations, itching, and rashes. If these effects persist or worsen, it is advisable to consult your healthcare provider for guidance.

In addition to the common side effects, there are other potential reactions that some users have reported. These include lightheadedness, nervousness, feelings of excitement, confusion, dizziness, drowsiness, ringing in the ears, blurred or double vision, vomiting, twitching, and tremors. In more serious instances, seizures, unconsciousness, or shallow breathing may occur. If you experience any of these symptoms, particularly if they are severe, you should contact your healthcare provider.

Rare but serious side effects require immediate medical attention. These include signs of an allergic reaction such as trouble breathing, swelling, low blood pressure, and rash. Another serious condition, methemoglobinemia, can manifest as blue or gray skin color, seizures, coma, and changes in heart rate or rhythm. If you experience any of these severe symptoms, seek urgent medical care without delay. Always remain vigilant about your health and report any unusual side effects to your healthcare provider.