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Fentanyl is a potent opioid with a high potential for abuse and addiction, which may result in overdose and death. It can also cause severe and potentially fatal breathing problems. Therefore, transdermal patches should only be used if you have been routinely using moderate to large amounts of opioid pain medication. Otherwise, there is a risk of overdose, which can be fatal. To reduce this risk, your healthcare provider should prescribe the smallest effective dose and the shortest duration of use.

• Consult your doctor or pharmacist to see if you should have naloxone available to counteract an opioid overdose. Family members or those living with you should be educated on recognizing the signs of an overdose and how to respond.

• The likelihood of serious breathing problems is higher when starting this medication, after a dose increase, or if used incorrectly. Combining fentanyl with alcohol or other substances that cause drowsiness or breathing difficulties can lead to serious side effects, including death.

• If you experience any serious side effects like slow or shallow breathing, unusual lightheadedness, severe drowsiness or dizziness, or difficulty waking up, seek medical assistance immediately.

• Do not use fentanyl for minor, short-term, or sudden pain, such as headaches, dental procedures, or post-surgical pain if you do not require overnight hospitalization. It is not intended for occasional use.

• Different forms of fentanyl (e.g., lozenges, buccal tablets, patches) are not interchangeable in terms of strength and effects. Discuss all medications you use with your healthcare provider, especially those that could influence how fentanyl works. Do not alter your medication regimen without consulting your doctor.

• Follow the manufacturer's instructions carefully for using transdermal patches. These patches are solely for skin application. Misuse, like chewing or using damaged patches, can lead to a fatal overdose. Avoid raising your skin temperature at the patch site using heating pads, electric blankets, hot tubs, or tanning lamps. You can bathe, shower, or swim with the patch as long as you avoid hot water.

• Women of childbearing age should discuss the risks and benefits of using fentanyl with their doctor, especially if pregnant or planning pregnancy. During pregnancy, use is advised only when necessary, as it may slightly increase the risk of birth defects in the first two months. Prolonged or high-dose use near delivery can harm the unborn baby. Babies exposed to this drug for an extended time may develop severe withdrawal symptoms. Contact a doctor immediately if your newborn shows symptoms like excessive crying, breathing difficulties, irritability, shaking, vomiting, diarrhea, poor feeding, or difficulty gaining weight.

• Store this medication securely to prevent theft, misuse, or abuse. It is not recommended for children under 2 years, and some manufacturers advise against use in individuals younger than 18. If ingested accidentally, seek medical help immediately.

You may experience some common side effects like nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, or headache. Mild irritation, itching, or redness at the application site can also occur. These effects often improve as your body adjusts to the medication. If they persist or worsen, contact your healthcare provider. To help prevent constipation, incorporate dietary fiber, stay hydrated, and exercise regularly; a pharmacist can advise on suitable laxatives if needed. To minimize dizziness and lightheadedness, rise slowly from sitting or lying positions.

Serious side effects are less common but require immediate attention. These include interrupted breathing during sleep (sleep apnea), changes in mood or mental state (such as agitation or hallucinations), intense abdominal pain, urinary difficulties, irregular heartbeat, and signs of adrenal gland issues like loss of appetite or unusual tiredness. Seek urgent medical care if you experience fainting, seizures, or have difficulty waking up due to severe drowsiness or slow breathing.

This medication can, though rarely, lead to serotonin syndrome, a serious condition. If you experience symptoms such as a rapid heartbeat, hallucinations, loss of coordination, severe dizziness, or unexplained fever, seek medical help promptly. Although rare, serious allergic reactions can occur, characterized by rash, severe itching or swelling, especially on the face, tongue, or throat, and difficulty breathing. If you notice these symptoms, seek immediate medical assistance.

This summary does not cover all possible side effects. If you have any concerns or notice other effects, consult your healthcare provider.

Certain products can interact with this medication. These include specific pain relievers (such as Butorphanol, Nalbuphine, pentazocine), Naltrexone, and samidorphan. Some medicines can change how your body processes fentanyl, possibly altering its effects. These include azole antifungals (like Itraconazole, Ketoconazole), calcium channel blockers (such as diltiazem, Verapamil), HIV protease inhibitors (such as nelfinavir), macrolide antibiotics (like Erythromycin), Mifepristone, Nefazodone, rifamycins (such as Rifabutin), Ritonavir, and certain seizure medications (such as Carbamazepine, Phenytoin).

Using MAO inhibitors with this drug can lead to a severe, potentially fatal interaction. Avoid MAO inhibitors (such as isocarboxazid, Linezolid, and others) while on this medication. Most MAO inhibitors should not be used for two weeks before starting this drug. Consult your doctor about when to begin or discontinue this medication.

There is an increased risk of serious side effects, such as slow or shallow breathing and severe drowsiness, when this medication is combined with other products that cause drowsiness or breathing issues. Inform your doctor or pharmacist if you are using other opioids (such as codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as Alprazolam, Lorazepam), muscle relaxants (such as Carisoprodol, Cyclobenzaprine), or antihistamines (such as Cetirizine, diphenhydramine).

Check the labels on your medicines for ingredients that cause drowsiness and consult your pharmacist about safe usage.

The risk of serotonin syndrome increases when this medication is taken with drugs that raise serotonin levels. This includes street drugs like MDMA, St. John's wort, and some antidepressants (such as SSRIs like Fluoxetine, SNRIs like Duloxetine). The risk is higher when you start or increase the dose of these drugs.

This medication may affect certain lab tests, such as amylase and lipase levels, leading to false results. Ensure that lab personnel and all your healthcare providers are aware of your medication use.