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Diclofenac, available as a sodium topical gel (such as Voltaren) or solution (Pennsaid), is used to relieve pain and inflammation associated with osteoarthritis, particularly in the knees, hands, and wrists. This medication, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the enzymes COX-1 and COX-2, which are responsible for producing prostaglandins—chemicals that cause pain and swelling. By reducing these prostaglandins, diclofenac helps alleviate joint discomfort and improve mobility. The gel is applied to the skin of the affected area up to four times daily. While the 1% gel can be purchased over-the-counter or with a prescription, the solution is available only by prescription. Common side effects may include dry skin, redness, and itching. As with other NSAIDs, there is a potential risk of more severe side effects such as blood clots and high blood pressure. Always consult with a healthcare professional before beginning any new medication regimen to ensure it is appropriate for your condition.