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When considering the use of diclofenac, it is vital to be aware of several safety warnings and potential risks. Below is a summary of important safety information to discuss with your healthcare provider:

• Heart Attack and Stroke Risk: Diclofenac may increase the likelihood of blood clots, heart attacks, or strokes, potentially occurring early in treatment. Risks are higher for individuals with heart issues, those using high doses, or using it long-term. Avoid use around heart bypass surgery. Seek immediate medical attention for chest pain, breathing difficulties, unilateral weakness, or speech issues.

• Gastrointestinal Bleeding: This medication can cause serious stomach or intestinal bleeding, sometimes without warning. The risk is elevated in older adults and those with a history of ulcers or stomach bleeding. Stop using diclofenac and contact a doctor if you experience persistent stomach pain, black/bloody stools, or vomit that resembles coffee grounds.

• Liver Damage: Rare but severe liver damage can occur, especially when combined with other liver-affecting medications like acetaminophen. Monitor for symptoms such as fatigue, nausea, yellow skin or eyes, or dark urine. Regular liver function tests may be necessary for long-term users.

• Blood Pressure and Heart Failure: Diclofenac may increase blood pressure and worsen heart failure symptoms by causing fluid retention. Monitor blood pressure regularly, and inform your healthcare provider about any changes or symptoms like swelling or unexpected weight gain.

• Kidney Damage: The risk of kidney damage is heightened when using certain blood pressure medications or in those with pre-existing kidney or liver issues. Report any changes in urination frequency to your healthcare provider.

• Asthma Attacks: Diclofenac can provoke severe asthma attacks in sensitive individuals, particularly those with a history of NSAID-induced asthma. Seek immediate help for breathing difficulties.

• Severe Allergic Reactions: Watch for signs of serious allergic reactions, such as rash, blisters, or facial swelling. Discontinue use and seek medical help if these occur.

• Pregnancy Risks: Using diclofenac during the second or third trimester can harm an unborn baby, leading to kidney or heart problems. Discuss risks and benefits with your provider if you are pregnant or planning to become pregnant.

Contraindications: Avoid using diclofenac if you have experienced asthma, hives, or allergic reactions to aspirin or other NSAIDs, or if you are scheduled for or recovering from heart bypass surgery.

These precautions and risks are crucial to consider before starting diclofenac. Ensure to have a detailed discussion with your healthcare provider to understand the benefits and potential dangers of this medication.

When using this medication, you might experience some common side effects. These include skin irritation such as dryness, redness, stinging, or rash. It's reassuring to know that these effects are generally mild and often temporary. However, if they persist or worsen, it's a good idea to consult your healthcare provider. Drowsiness and dizziness are also possible, so be cautious when performing activities that require alertness.

It's important to be aware that this medication might raise your blood pressure. Regularly monitor your blood pressure and inform your healthcare provider if you notice any significant changes. Additionally, some users have reported experiencing acid reflux, bloating, and stomach pain, which are worth mentioning to your healthcare provider if they occur.

Serious side effects, although rare, need immediate attention. These include symptoms of kidney problems, such as changes in urine output, or signs of heart failure like swelling of the ankles or feet, unusual tiredness, and sudden weight gain. This medication can also rarely cause severe liver damage. Seek urgent medical help if you experience persistent nausea, vomiting, loss of appetite, stomach pain, yellowing of the eyes or skin, or dark urine.

In very rare cases, a severe allergic reaction may occur. Be alert for symptoms like fever, swollen lymph nodes, severe rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. If you notice any of these, seek emergency medical care immediately. While this isn't a comprehensive list of side effects, it's essential to discuss any unexpected changes in your health with your healthcare provider.

When using diclofenac, it's important to be aware of potential interactions with other medications. Certain drugs may increase the risk of side effects or affect how diclofenac works. For example, combining diclofenac with aliskiren, ACE inhibitors like captopril and lisinopril, or angiotensin II receptor blockers such as losartan and valsartan, can alter blood pressure control. Additionally, drugs like cidofovir, corticosteroids (e.g., dexamethasone, prednisone), lithium, methotrexate, and diuretics like furosemide may have interactions that require careful monitoring by your healthcare provider.

Diclofenac can also increase bleeding risk when taken with medications that affect blood clotting. These include anti-platelet drugs like clopidogrel or blood thinners such as dabigatran, enoxaparin, and warfarin. It's crucial to inform your doctor of all medications you take, including over-the-counter drugs and supplements, as some, like aspirin and NSAIDs (such as ibuprofen, ketorolac, or naproxen), are similar to diclofenac and can heighten the chance of adverse effects.

If you are prescribed low-dose aspirin to prevent heart attacks or strokes, continue its use unless advised otherwise by your doctor. Always consult with your healthcare provider or pharmacist for guidance on managing these interactions and adjusting any dosages as necessary.