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Tacrolimus is a medication that has shown benefits when used appropriately, though its long-term safety remains under study. There have been rare instances of cancers, such as skin cancer and lymphoma, reported in individuals using tacrolimus on the skin, though a direct link has not been established. Below are important safety considerations and warnings to keep in mind:

• Cancer Risk: Some users of tacrolimus have reported rare cases of skin and lymphoma cancer. It is crucial to apply the ointment strictly as prescribed, avoiding use on unaffected areas and limiting the duration of treatment. If symptoms persist beyond six weeks, consult with your healthcare provider for a reassessment.

• Immune System Impact: Prolonged use of tacrolimus may weaken the immune system. Monitor for signs of infection and inform your healthcare provider if you experience any.

• Infection Risk: Tacrolimus may increase the risk of developing infections like chickenpox, shingles, and other herpes infections. Avoid applying the medication to infected areas. If an infection develops, discontinue use and contact your healthcare provider for further guidance.

• Swollen Lymph Nodes: Report any swollen lymph nodes to your healthcare provider, as this might indicate an infection or a more serious condition requiring discontinuation of the medication.

• Sun Exposure: Tacrolimus can affect your skin's response to sunlight, increasing the risk of sunburn. Use sunscreen, wear protective clothing, and avoid tanning beds and direct sunlight during treatment.

• Renal Concerns: In rare cases, tacrolimus has been associated with sudden kidney failure, especially when applied over large skin areas with compromised skin barriers. Discuss any concerns with your healthcare provider.

• Usage Guidelines: This drug should be reserved for situations where other treatments have failed or are not suitable. Use the smallest effective amount and restrict its use to affected skin only. Tacrolimus is not recommended for children under 2 years of age.

Always discuss the potential risks and benefits of tacrolimus with your healthcare provider to ensure its safe and effective use. In the event of unusual symptoms such as lumps, swollen glands, or growths, seek medical advice promptly.

When using this medication, some individuals may experience mild side effects such as burning, itching, or soreness of the skin, particularly in the initial days of treatment. These sensations are generally temporary. Flu-like symptoms, which may include fever, chills, runny nose, and muscle aches, can also occur. Other common side effects include headaches and increased sensitivity to temperature changes or touch. Most people find these symptoms manageable and they often resolve on their own. However, if they persist or become bothersome, it's advisable to consult with a healthcare provider.

There are more serious side effects that are rare but require immediate attention if they occur. These include severe fatigue, muscle or joint pain, skin infections or sores like chicken pox or shingles, unusual chest pain, or any appearance of tumors or warts. It is essential to seek urgent medical care if you experience any of these symptoms.

Additionally, though a very serious allergic reaction is rare, be vigilant for signs such as rash, severe dizziness, or difficulty breathing, and seek medical help immediately if they occur. This list does not cover all possible side effects, so you should reach out to a healthcare provider if you notice any other concerning symptoms.