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Methylcobalamin is often considered the best-absorbed form of vitamin B12. It is a naturally occurring form that is readily utilized by the body.

The fastest way to address a vitamin B12 deficiency is through vitamin B12 injections, as they allow for direct absorption into the bloodstream. This method is typically used for individuals with severe deficiencies or absorption issues. Oral supplements or sublingual tablets can also be effective, especially for those with mild deficiencies or dietary insufficiencies. It is important to consult with a healthcare provider to determine the appropriate treatment plan based on the individual's specific needs and health status.

Individuals who should avoid taking methylcobalamin include those with an allergy to cobalamin or cobalt. Additionally, people with Leber's disease, a hereditary eye condition, should not take methylcobalamin as it may worsen the condition. It is also important for individuals with certain medical conditions or those who are pregnant or breastfeeding to consult a healthcare provider before using methylcobalamin.