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Colchicine

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generic Colcrys, Mitigare, Gloperba

This medication is used to prevent or treat gout attacks (flares). Usually gout symptoms develop suddenly and involve only one or a few joints. The big toe, knee, or ankle joints are most often affected. Gout is caused by too much uric acid in the blood. When uric acid levels in the blood are too high, the uric acid may form hard crystals in your joints. Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint(s). This medication is also used to prevent attacks of pain in the abdomen, chest, or joints caused by a certain inherited disease (familial Mediterranean fever). It is thought to work by decreasing your body's production of a certain protein (amyloid A) that builds up in people with familial Mediterranean fever. Colchicine is not a pain medication and should not be used to relieve other causes of pain.
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0.6MG, Colchicine (30 Tablets)

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$19.71

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Colchicine Side Effects

Diarrhea, nausea, cramping, abdominal pain, and vomiting may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Stop taking this medication and get medical help right away if you have any very serious side effects, including: unusual bleeding/bruising, severe diarrhea or vomiting, muscle weakness or pain, numbness/tingling in your fingers or toes, pale or gray color of the lips/tongue/palms of hands, signs of infection (such as sore throat that doesn't go away, fever), unusual weakness/tiredness, fast heartbeat, shortness of breath, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

Other medications can affect the removal of colchicine from your body, which may affect how colchicine works or increase the risk of serious side effects. Examples include atazanavir, certain azole antifungals (such as itraconazole, ketoconazole), diltiazem, macrolide antibiotics (such as clarithromycin, erythromycin), ritonavir, telithromycin, verapamil, among others. Colchicine may rarely cause a certain serious (even fatal) muscle damage (rhabdomyolysis). This muscle damage releases substances that can lead to serious kidney problems. The risk may be increased if other drugs that may also cause rhabdomyolysis are taken along with colchicine. Some affected drugs include: digoxin, gemfibrozil, pravastatin, simvastatin, among others. This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug. Do not take this medication with any other product that contains colchicine.
Colchicine FAQs
What does colchicine do exactly?

Colchicine is a medication primarily used to treat and prevent gout attacks. It works by reducing inflammation and decreasing the build-up of uric acid crystals in the joints, which helps alleviate pain and swelling. Additionally, colchicine is sometimes used to treat familial Mediterranean fever and other inflammatory conditions as prescribed by a healthcare provider.

Colchicine does not clear uric acid from the body. Instead, it is used to reduce inflammation and relieve pain during acute gout attacks. It works by decreasing the build-up of uric acid crystals that cause joint pain. For lowering uric acid levels, medications such as allopurinol or febuxostat are typically prescribed.

A bad reaction to colchicine can include symptoms such as severe diarrhea, nausea, vomiting, abdominal pain, and muscle weakness. In some cases, it can also cause bone marrow suppression, leading to low blood cell counts, which may result in increased risk of infections, fatigue, or unusual bleeding. If any of these symptoms occur, it is important to seek medical attention promptly.

Colchicine is primarily used to treat and prevent gout attacks by reducing inflammation and pain. It is also used in the management of familial Mediterranean fever (FMF) to prevent flare-ups. Additionally, colchicine may be prescribed for pericarditis to reduce inflammation of the pericardium. It is important for patients to follow their healthcare provider's instructions when using colchicine to ensure its effectiveness and minimize potential side effects.

Individuals who should avoid colchicine include those with severe renal or hepatic impairment, as the drug can accumulate to toxic levels in these conditions. Additionally, people with known hypersensitivity to colchicine should not take it. Caution is also advised for those taking medications that strongly inhibit CYP3A4 or P-glycoprotein, as these can increase colchicine levels and risk of toxicity. Pregnant or breastfeeding women should consult their healthcare provider before using colchicine.

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