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Quinacrine is used primarily as an antimalarial medication. It has also been used in the treatment of giardiasis and certain autoimmune conditions, such as lupus erythematosus.

Quinacrine was taken off the market primarily due to concerns about its safety profile and the availability of safer alternatives. It was associated with potential side effects, including liver toxicity and aplastic anemia, which led to its decline in use. Additionally, newer medications with improved safety and efficacy profiles became available, further reducing the need for quinacrine.

Serious side effects of quinacrine may include severe allergic reactions, such as rash, itching, swelling, dizziness, and trouble breathing. Other serious side effects can involve changes in vision, severe headache, confusion, seizures, and signs of liver problems like yellowing of the skin or eyes, dark urine, and persistent nausea or vomiting. It is important to seek medical attention if any of these symptoms occur.

An alternative to quinacrine may depend on the condition being treated. For example, if quinacrine is being used for the treatment of lupus, alternatives might include hydroxychloroquine or chloroquine. It is important for the patient to consult with a healthcare provider to determine the most appropriate alternative based on their specific medical needs and condition.

An alternative to hydroxychloroquine for the treatment of lupus may include medications such as methotrexate, azathioprine, or mycophenolate mofetil. The choice of medication depends on the individual's specific symptoms and medical history, and it is important for patients to discuss options with their healthcare provider to determine the most appropriate treatment plan.