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The following safety information outlines important warnings and precautions associated with the use of this medication. Please review these carefully and consult your healthcare provider if you have any questions or concerns.

• Serious Allergic Reactions: In rare instances, RhoGAM can trigger severe allergic responses. Individuals who lack the IgA antibody may face a heightened risk due to the presence of a small amount of IgA in RhoGAM. Such reactions can occur even if you have previously received this injection. Healthcare professionals will monitor you for at least 20 minutes post-injection. Be vigilant for symptoms such as wheezing, chest tightness, difficulty breathing, low blood pressure, dizziness, vomiting, itchy rash, hives, and swelling of the tongue or throat. Seek immediate medical assistance if these symptoms arise. Particularly at risk are individuals with low levels of immune globulin A (IgA).

• Potential Infection Risk: As RhoGAM is derived from human blood products, there is a minimal risk of transmitting viruses or harmful proteins, including variant Creutzfeldt-Jakob disease (vCJD). This risk remains low due to rigorous donor screening and laboratory testing. If you suspect an infection following the use of this medication, contact your healthcare provider promptly. Discuss with your healthcare team the potential benefits and risks associated with RhoGAM.

• Red Blood Cell Breakdown: Individuals who are Rh-positive may experience the breakdown of red blood cells after receiving RhoGAM. Your healthcare provider will monitor you for any blood-related issues. Report symptoms such as fever, back pain, nausea, vomiting, shaking, chills, changes in blood pressure, discolored urine, or blood in urine to your healthcare team immediately. These symptoms may not appear right away, so remain vigilant and inform your healthcare provider if they occur later.

• Vaccine Interaction: RhoGAM can interfere with the effectiveness of live vaccines, such as MMR (measles, mumps, and rubella) and Varivax (varicella vaccine), by weakening the body's response. Additionally, it may increase the risk of infection from these vaccines. Live vaccines are generally not recommended within 12 weeks of receiving RhoGAM. If you have recently given birth and require the MMR vaccine, a blood test 12 weeks later will confirm vaccine efficacy. Discuss your vaccination schedule with your healthcare provider before receiving RhoGAM.

Contraindications:

• Do not use this medication if you have Rh-positive blood.
• Avoid RhoGAM if you have a history of allergic reactions to human immunoglobulin products.

These guidelines are crucial for ensuring the safe and effective use of RhoGAM. Always consult your healthcare provider to determine the best course of action for your specific health needs.

When taking this medication, some individuals may experience certain side effects, which can vary in severity. Commonly reported mild side effects include reactions at the injection site, such as swelling, redness, pain, or tenderness. These are generally mild but should be discussed with a healthcare provider if they persist or become bothersome.

Other side effects that some people may encounter are mild fever, skin rash, and body aches. While these are generally not cause for alarm, it is advisable to monitor them and consult a healthcare provider if they continue or worsen.

In rare instances, serious side effects may occur, requiring prompt medical attention. These include severe allergic reactions characterized by symptoms like wheezing, chest tightness, difficulty breathing, low blood pressure, dizziness, vomiting, itchy rash, hives, or swelling of the tongue or throat. Additionally, a serious condition involving the breakdown of red blood cells might arise, presenting symptoms such as fever, back pain, nausea, vomiting, shaking, chills, changes in blood pressure, or discolored urine. Immediate medical care is essential if any of these severe symptoms manifest.