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This safety information outlines important warnings and precautions for the use of rifabutin (Mycobutin). Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

• Tuberculosis Precaution: Rifabutin (Mycobutin) should not be used for the treatment of tuberculosis (TB). Utilizing it for TB prevention may lead to antibiotic resistance. If you have active TB, a combination of different anti-TB antibiotics is necessary. Your healthcare provider will assess you for TB before starting rifabutin and will monitor you regularly during the course of treatment to prevent a TB infection.

• Drug Interactions: Rifabutin (Mycobutin) can interact with many medications, such as clarithromycin and protease inhibitors used in HIV treatment. Ensure that all your healthcare providers and pharmacists are informed of all the medications you are taking to avoid interactions and ensure appropriate dosing.

• Allergic Reactions and Skin Issues: Serious allergic reactions, including anaphylaxis, can occur with rifabutin (Mycobutin). Seek immediate medical attention if you experience symptoms such as dizziness, rash, hives, facial or tongue swelling, difficulty breathing, or flu-like symptoms.

• Eye Inflammation: Though rare, rifabutin (Mycobutin) can cause uveitis, an inflammation in the eye, especially if taken with medications like clarithromycin, azithromycin, or fluconazole. Notify your provider if you experience eye redness, pain, blurred vision, or sensitivity to light.

• Infectious Diarrhea Risk: Antibiotics, including rifabutin (Mycobutin), can increase the risk of a serious gut infection leading to severe diarrhea, which may occur even after treatment completion. Contact your provider if you develop severe diarrhea with watery stools.

• Blood Cell Monitoring: Rifabutin (Mycobutin) may lead to low counts of white blood cells and platelets. Regular blood tests will be conducted by your provider to monitor these levels during treatment.

Contraindications: Do not use rifabutin (Mycobutin) if you have an allergy to rifamycins. Consult your healthcare provider if this applies to you.

Common side effects:

• Change in urine color
• Low blood cell count
• Rash
• Higher liver enzymes
• Nausea

Less common but important to monitor:

• Stomach pain
• Fever
• Headache
• Low appetite
• Diarrhea
• Upset stomach
• Excessive gas
• Vomiting
• Muscle pain
• Change in taste

Serious side effects:

• Severe skin or allergic reactions (fever, body aches, rash, swelling of lips or tongue, trouble breathing, blistering or peeling skin)
• Infectious diarrhea (fever, fatigue, stomach pain, watery diarrhea, frequent loose stools)

Rifabutin is an antibiotic commonly used to prevent and treat infections caused by certain bacteria, including Mycobacterium avium complex (MAC) in individuals with weakened immune systems. It's important to be aware that rifabutin can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects.

One notable interaction occurs with certain antiretroviral drugs used to treat HIV. Rifabutin can affect the levels of these medications in the blood, which may require adjustments to their dosages to maintain their effectiveness and minimize side effects.

Additionally, rifabutin may interact with oral contraceptives, potentially reducing their effectiveness. Individuals using hormonal birth control methods should discuss alternative or additional contraceptive measures with their healthcare provider while taking rifabutin.

Other medications that may interact with rifabutin include antifungal agents, certain antibiotics, and drugs metabolized by the liver's cytochrome P450 enzyme system. These interactions can lead to either increased or decreased levels of the medications involved, affecting their efficacy and safety.

To ensure safe and effective treatment, it's crucial to inform your healthcare provider about all medications, supplements, and herbal products you are currently using before starting rifabutin. Your provider can assess potential interactions and make necessary adjustments to your treatment plan.