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Rifabutin

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generic Mycobutin

Rifabutin, known by its brand name Mycobutin, is a rifamycin antibiotic used to prevent Mycobacterium avium complex (MAC) infections, particularly in individuals with advanced HIV. It functions by inhibiting the growth of bacteria, effectively obstructing an enzyme essential for bacterial replication, which halts the spread of the infection. This medication is specifically for bacterial infections and is ineffective against viral infections like the flu or common cold. It is typically administered orally in capsule form once daily. It's important to note that misuse of antibiotics can lead to decreased effectiveness in future infections. Users may experience a temporary change in the color of their teeth, body fluids, and urine as a side effect. Always consult with a healthcare professional before starting any new medication.
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Rifabutin WarningsRifabutin Side EffectsRifabutin InteractionsFAQs

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150MG, Rifabutin (30 Capsules)

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$195.42

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Rifabutin dosage forms

The average cost for 30 Capsules of Rifabutin (generic Mycobutin) at 150MG is $134.45 with a free coupon. This is 26.88% off the average retail price of $500.1
DosageQuantityPrice fromPer unit
150MG30 Capsules$134.45$4.48

Rifabutin Warnings

This safety information outlines important warnings and precautions for the use of rifabutin (Mycobutin). Please review these details carefully and consult your healthcare provider if you have any questions or concerns.

  • Tuberculosis Precaution: Rifabutin (Mycobutin) should not be used for the treatment of tuberculosis (TB). Utilizing it for TB prevention may lead to antibiotic resistance. If you have active TB, a combination of different anti-TB antibiotics is necessary. Your healthcare provider will assess you for TB before starting rifabutin and will monitor you regularly during the course of treatment to prevent a TB infection.

  • Drug Interactions: Rifabutin (Mycobutin) can interact with many medications, such as clarithromycin and protease inhibitors used in HIV treatment. Ensure that all your healthcare providers and pharmacists are informed of all the medications you are taking to avoid interactions and ensure appropriate dosing.

  • Allergic Reactions and Skin Issues: Serious allergic reactions, including anaphylaxis, can occur with rifabutin (Mycobutin). Seek immediate medical attention if you experience symptoms such as dizziness, rash, hives, facial or tongue swelling, difficulty breathing, or flu-like symptoms.

  • Eye Inflammation: Though rare, rifabutin (Mycobutin) can cause uveitis, an inflammation in the eye, especially if taken with medications like clarithromycin, azithromycin, or fluconazole. Notify your provider if you experience eye redness, pain, blurred vision, or sensitivity to light.

  • Infectious Diarrhea Risk: Antibiotics, including rifabutin (Mycobutin), can increase the risk of a serious gut infection leading to severe diarrhea, which may occur even after treatment completion. Contact your provider if you develop severe diarrhea with watery stools.

  • Blood Cell Monitoring: Rifabutin (Mycobutin) may lead to low counts of white blood cells and platelets. Regular blood tests will be conducted by your provider to monitor these levels during treatment.

Contraindications: Do not use rifabutin (Mycobutin) if you have an allergy to rifamycins. Consult your healthcare provider if this applies to you.

Rifabutin Side Effects

Common side effects:

  • Change in urine color
  • Low blood cell count
  • Rash
  • Higher liver enzymes
  • Nausea

Less common but important to monitor:

  • Stomach pain
  • Fever
  • Headache
  • Low appetite
  • Diarrhea
  • Upset stomach
  • Excessive gas
  • Vomiting
  • Muscle pain
  • Change in taste

Serious side effects:

  • Severe skin or allergic reactions (fever, body aches, rash, swelling of lips or tongue, trouble breathing, blistering or peeling skin)
  • Infectious diarrhea (fever, fatigue, stomach pain, watery diarrhea, frequent loose stools)

Rifabutin Interactions

Some products that may interact with this drug include: azole antifungals (such as fluconazole, itraconazole, voriconazole), ciprofloxacin, macrolide antibiotics (such as clarithromycin). Rifabutin can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aprepitant/fosaprepitant, lurasidone, mavacamten, phenytoin, ranolazine, suvorexant, tacrolimus, tasimelteon, blood thinners (such as warfarin), calcium channel blockers (such as diltiazem, verapamil), among others. This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.
Rifabutin FAQs
What is rifabutin used to treat?

Rifabutin is primarily used to treat and prevent Mycobacterium avium complex (MAC) infections, particularly in individuals with HIV. It is also used as part of combination therapy for tuberculosis in certain cases.

Yes, rifabutin is a medication used in the treatment of tuberculosis (TB). It is often used as part of a combination therapy for TB, especially in patients who are also receiving medications for HIV, due to its lower potential for drug interactions compared to rifampin.

Rifabutin and rifampin are not the same, though they are both antibiotics belonging to the rifamycin class. They are used to treat different types of bacterial infections and have different pharmacokinetic properties and side effect profiles. It is important to use them as prescribed by a healthcare professional for their specific indications.

The best antibiotics for treating tuberculosis (TB) typically include a combination of isoniazid, rifampin, ethambutol, and pyrazinamide. This combination is often used in the initial phase of treatment to effectively combat the Mycobacterium tuberculosis bacteria. Treatment regimens can vary based on individual patient factors and drug susceptibility, so it is important for a healthcare provider to tailor the treatment plan accordingly.

The major adverse effect of rifabutin is uveitis, which is an inflammation of the uvea in the eye. It can also cause other side effects such as neutropenia, rash, and gastrointestinal disturbances. Regular monitoring is recommended for patients on rifabutin therapy.

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