Asenapine

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asenapine

Asenapine, marketed under the brand name Saphris, is an atypical antipsychotic medication used to treat mental/mood disorders such as schizophrenia in adults and bipolar I disorder in individuals aged 10 years and older. This medication comes in the form of sublingual tablets, which are placed under the tongue to dissolve, with a typical dosage being twice daily. Asenapine works by modulating the activity of dopamine and serotonin, key neurotransmitters in the brain, thereby helping to balance thoughts, mood, and behaviors. While effective, some users may experience side effects such as drowsiness, insomnia, and motor disturbances. Always consult a healthcare professional before starting or altering any medication regimen.
Our Saphris coupons are free to use. You can print the coupon, email it to yourself, or receive the Saphris coupon via text message. To get your free discount, show the pharmacist your Saphris savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Saphris prices will update based on your prescription needs. Above our Saphris coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Saphris savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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10MG, Asenapine (30 Tablet Sublinguals)

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CVS

$62.22

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$89.32

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$101.02

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$166.52

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$62.22

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Saphris dosage forms

The average cost for 30 Tablet Sublinguals of Saphris (asenapine) at 5MG is $53.76 with a free coupon. This is 8.29% off the average retail price of $648.3
DosageQuantityPrice fromPer unit
5MG30 Tablet Sublinguals$53.76$1.79
10MG30 Tablet Sublinguals$61.74$2.06
2.5MG30 Tablet Sublinguals$61.74$2.06

Saphris Warnings

Asenapine (Saphris) is associated with several important safety warnings and precautions. Please review the following information carefully and discuss any concerns with your healthcare provider.

  • Increased Risk in Older Adults with Dementia: Older individuals over 65 years old with dementia who take asenapine for psychosis may face a heightened risk of death, often due to heart issues or infections. Asenapine is not approved for treating dementia-related behavior problems. Consider discussing alternative treatments with your doctor.

  • Neuroleptic Malignant Syndrome (NMS): This is a rare but potentially life-threatening condition linked to antipsychotic drugs. Symptoms include high fever, rapid heartbeat, muscle stiffness, and confusion. Seek immediate medical attention if these symptoms occur, as a medication change might be necessary.

  • Movement Disorders: Long-term use of asenapine can lead to tardive dyskinesia (TD), characterized by involuntary movements such as lip smacking or unusual blinking. This condition may be irreversible. To minimize the risk, the lowest effective dose will be prescribed, and regular assessments of your need for continued use will be conducted. Report any TD symptoms to your healthcare provider promptly.

  • Metabolic Changes: Asenapine can cause high blood sugar, elevated cholesterol, and weight gain, increasing the risk of heart disease and other serious health conditions. Discuss preventive strategies with your healthcare provider.

  • Allergic Reactions: Though rare, serious allergic reactions may occur. Seek medical help immediately if you experience symptoms such as rash, rapid heartbeat, swelling, or difficulty breathing.

  • Blood Pressure and Heart Rate Changes: Asenapine may cause low blood pressure and changes in heart rhythm, particularly when standing up. If you have a history of heart issues or are taking medications that affect blood pressure or heart rhythm, consult your healthcare provider. Report any dizziness or abnormal heartbeats to your care team.

  • Low White Blood Cell Count: This medication can reduce white blood cells, increasing infection risk. Notify your doctor if you experience fever or frequent infections. Blood tests may be required to monitor white blood cell levels.

  • Seizures: Those with a history of seizures or conditions that increase seizure risk should inform their prescriber before starting asenapine.

  • Elevated Prolactin Levels: Asenapine can increase prolactin levels, potentially causing menstrual changes, fertility issues, and mood or sexual problems. Discuss any concerns with your healthcare team.

  • Phenylketonuria (PKU): Some asenapine formulations contain phenylalanine, which is harmful to individuals with PKU. Ensure your prescriber is aware of your condition.

  • Contraindications: Asenapine should not be used by individuals with severe liver problems.

In case of an overdose, seek emergency medical attention immediately. Always adhere to your healthcare provider’s instructions and consult them before making any changes to your medication regimen.

Saphris Side Effects

When using this medication, some common side effects might be experienced, though they are usually mild and manageable. These include trouble sleeping, drowsiness, dizziness, constipation, vomiting, numbness or tingling in the mouth, and increased appetite, potentially leading to weight gain. It's important to rise slowly from sitting or lying positions to reduce the risk of dizziness and falls.

Other side effects that may occur include dry mouth, excessive salivation, fatigue, irritability, and stomach discomfort. While most people tolerate these effects well, consult your healthcare provider if they persist or worsen.

More serious side effects, though rare, demand immediate medical attention. These include symptoms of neuroleptic malignant syndrome, such as high fever, sweating, confusion, muscle stiffness, and changes in blood pressure. Other severe reactions can include seizures, significant mood changes or thoughts of self-harm, and changes in heartbeat.

For males, there is a rare risk of a prolonged or painful erection lasting more than four hours, which requires emergency medical help. Additionally, some individuals may experience a serious allergic reaction, characterized by rash, hives, difficulty breathing, or swelling of the face, tongue, or throat.

In rare cases, the medication can increase blood sugar levels, potentially affecting diabetes management. For women, increased prolactin levels may cause issues like unwanted breast milk or menstrual changes, while men might experience decreased sexual ability or enlarged breasts. If any of these occur, contact your healthcare provider promptly. Always keep open communication with your healthcare provider to manage any side effects effectively.

Saphris Interactions

Asenapine may impact the effectiveness of other medications by slowing their elimination from the body. This is particularly relevant for medications like paroxetine. It is important to inform your healthcare provider if you are using other substances that can cause drowsiness. These include opioid painkillers or cough suppressants such as codeine and hydrocodone, alcohol, marijuana, anxiety or sleep medications like alprazolam, lorazepam, and zolpidem, muscle relaxants such as carisoprodol and cyclobenzaprine, and antihistamines like cetirizine and diphenhydramine.

Additionally, asenapine may have significant interactions with certain medications, which your doctor might need to consider before prescribing. Some medicines should not be used with asenapine, such as bepridil, bromopride, cisapride, dronedarone, mesoridazine, metoclopramide, pimozide, piperaquine, saquinavir, sparfloxacin, terfenadine, thioridazine, and ziprasidone. For other medications, including acecainide, ajmaline, alfentanil, and many others listed, concurrent use with asenapine is generally not recommended unless necessary. In such cases, your doctor may adjust the dosage or frequency of use.

Finally, while asenapine and paroxetine together may heighten the risk of side effects, this combination might be essential for your treatment plan, and your healthcare provider will manage the dosages accordingly. Always consult with your doctor or pharmacist when taking any new medication or supplement to ensure safe and effective treatment.

Saphris FAQs
What is the drug Saphris used for?

Saphris is used to treat certain mental/mood disorders such as schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain, which can improve mood, behavior, and thinking.

Yes, Saphris (asenapine) can cause weight gain as a side effect. However, the extent of weight gain can vary among individuals. It is important for patients to discuss any concerns about side effects with their healthcare provider.

Saphris (asenapine) is primarily used to treat symptoms of schizophrenia and bipolar disorder. While it is not specifically approved for treating anxiety, some patients with these conditions may experience a reduction in anxiety symptoms as a secondary benefit. However, it is important for individuals to consult with their healthcare provider to determine the most appropriate treatment for their specific condition.

Asenapine is not classified as a sedative. It is an atypical antipsychotic medication used primarily to treat conditions such as schizophrenia and bipolar disorder. While it may have sedative effects as a side effect, its primary function is not sedation.

Yes, there are bipolar medications that are less likely to cause weight gain. Medications such as lamotrigine and certain atypical antipsychotics like aripiprazole and lurasidone are generally considered to have a lower risk of weight gain compared to others. However, individual responses to medications can vary, so it is important for a patient to discuss options with their healthcare provider to find the most suitable treatment.