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Sirolimus is known to reduce the immune system's ability to combat infections and diseases, which can heighten the risk of infections and certain cancers, including skin cancer and lymphoma. To minimize these risks, it is essential to take this medication in the smallest effective dose as prescribed by your healthcare provider. Ensure you attend all scheduled medical and laboratory appointments.

Be vigilant for any of the following symptoms and report them to your doctor immediately: unusual changes in your skin, alterations in the size or appearance of moles, new growths or lumps, swollen lymph nodes, night sweats, unexplained weight loss, or persistent signs of infection like a sore throat or fever.

Note that Sirolimus is not recommended for preventing rejection in liver or lung transplants due to rare, yet potentially fatal, complications with the liver or lungs associated with its use in these scenarios.

Common side effects of this medication may include diarrhea, joint pain, shaking, acne, or difficulty sleeping. These are usually mild and temporary, but if they persist or worsen, it is important to inform your healthcare provider. Most individuals taking this medication do not experience severe side effects, which reflect the balance of benefits over risks.

However, there are serious side effects that require immediate attention. These include persistent nausea or vomiting, yellowing of the eyes or skin, dark urine, muscle or bone pain, increased thirst or hunger, frequent urination, hearing issues, unusual tiredness, irregular heartbeat, easy bruising, mood changes, swelling in the ankles or feet, severe headaches, dizziness, abdominal pain, menstrual changes, symptoms of kidney issues, or swelling in the arms, legs, or abdomen.

If you experience chest pain or shortness of breath, seek medical assistance immediately, as these could be very serious. There is a risk of a rare but potentially fatal brain infection, signaled by symptoms such as clumsiness, loss of coordination, weakness, sudden changes in thinking, speech or movement difficulties, seizures, or vision changes. Additionally, sirolimus may slow surgical wound healing, particularly if you are obese, and could lead to increased cholesterol or triglyceride levels.

A rash may develop, often harmless, but it could indicate a severe reaction. Immediate medical help is necessary if this occurs. Though rare, very serious allergic reactions can happen, characterized by rash, itching, swelling, severe dizziness, or breathing difficulties. Always report any other unexpected side effects to your healthcare provider for guidance.