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The following safety information outlines critical warnings and contraindications associated with the use of this medication. It is essential to understand these risks and consult your healthcare provider with any concerns or questions.

• Blood Disorders: There is a rare risk of developing a serious blood disorder when taking acyclovir (Zovirax), particularly in individuals with weakened immune systems. Your healthcare provider may conduct blood tests during treatment. Seek medical attention immediately if you experience symptoms such as fever, unexplained bleeding or bruising, confusion, fatigue, nausea, vomiting, diarrhea, or dark urine. Conditions that weaken your immune system increase this risk.

• Kidney Problems: Acyclovir (Zovirax) can significantly impact kidney health, especially in older adults. If you have poor kidney function, the dosage may need adjustment. Dehydration and concurrent use of medications such as NSAIDs (e.g., ibuprofen, naproxen) can elevate this risk. It's important to maintain adequate hydration and consult your provider before using any other medications, including over-the-counter pain and cold remedies. Your provider might also monitor your kidney function through lab tests. Risk factors include being over the age of 65, existing kidney problems, and using other kidney-harming medications.

Contraindications: This medication should not be used under certain conditions due to potential health risks. If any of the following apply to you, discuss them with your healthcare provider before starting treatment:

• Allergy to acyclovir (Zovirax) or valacyclovir (Valtrex).
• Allergy to milk protein concentrate (specific to Sitavig formulation).

For any concerns or in the event of an emergency, contact your healthcare provider promptly.

When using this medication, some common side effects may occur, but they are generally mild and manageable. Up to 12% of users may experience a general feeling of being unwell, while nausea and/or vomiting affect up to 5%. Diarrhea is reported by up to 3% of users, and headaches occur in about 2-3% of individuals. Some individuals may also notice dizziness, low energy, or mild irritation, redness, or pain at the application site, each affecting around 1% of users. These symptoms often subside, but if they persist or worsen, consulting a healthcare provider is advisable.

There are also more serious side effects, although they are rare. A significant reaction at the application site occurs in about 5% of users and requires immediate medical attention. Additionally, although extremely rare, a severe allergic reaction may occur. Symptoms of a serious allergic reaction include rash, itching or swelling of the face, tongue, or throat, severe dizziness, and difficulty breathing. If any of these occur, it is crucial to seek urgent medical care. Always remain vigilant for any new or unusual symptoms and discuss them with your healthcare provider for further guidance.

Acyclovir should not be used in combination with medications containing valacyclovir, as they are very similar and taking both may increase the risk of side effects. Additionally, Acyclovir (Zovirax) can interact with other medications. Inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications may not be recommended for use with Acyclovir, but may be necessary in some situations. If prescribed together, your doctor might adjust the dosage or frequency of one or both medications. These include Dichlorphenamide, Foscarnet, Leflunomide, Nitisinone, and Teriflunomide.

There are also medications that, when used with Acyclovir, could increase the risk of side effects. However, using both could be the best treatment option for you. In such cases, your doctor may alter the dose or how often you take one or both. These medications include Fosphenytoin, Phenytoin, and Valproic Acid. Always follow your doctor's guidance when managing these interactions.