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The safety and warning information below highlights important considerations for those taking Valacyclovir (Valtrex). It is crucial to understand these potential risks and take necessary precautions. Always discuss any concerns with your healthcare provider.

• Rare Blood Clotting Disorders: Valacyclovir (Valtrex) may lead to severe blood disorders such as thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS), particularly in individuals with HIV or weakened immune systems taking more than 8 grams daily. Regular blood tests may be required to monitor your condition. Seek immediate medical attention if you experience symptoms like stomach pain, fever, unusual bleeding or bruising, fatigue, or blood in the urine. Those at higher risk include individuals with HIV, organ transplant recipients, and anyone consuming high doses.

• Kidney Issues: There is a rare but serious risk of kidney problems with Valacyclovir (Valtrex), especially in older adults or those on other kidney-impacting medications. Staying hydrated is essential. Contact your healthcare provider if you notice symptoms such as lower back pain, difficulty urinating, or swelling in extremities. Risks increase with dehydration, advanced age, excessive doses in individuals with pre-existing kidney issues, and concurrent use of other nephrotoxic drugs.

• Nervous System Effects: Use of Valacyclovir (Valtrex) can occasionally result in nervous system-related side effects, including agitation, confusion, hallucinations, or seizures. If you or those around you observe these symptoms, discontinue use and consult your provider. These effects are more common in older adults and those with kidney problems taking high doses.

In case of any adverse effects or concerns, healthcare guidance should be sought promptly to ensure safe and effective use of Valacyclovir (Valtrex).

When taking this medication, some people might experience mild side effects such as nausea, stomach pain, headache, or dizziness. These effects are usually manageable, but consult your healthcare provider if they persist or worsen. It's important to remember that the benefits of this medication often outweigh these minor side effects for most users.

In rare cases, more serious side effects can occur, and it's crucial to be aware of them. Contact your healthcare provider immediately if you notice symptoms like significant changes in urine output, unusual back or side pain, mental or mood changes such as confusion or hallucinations, shaky or unsteady movements, unusual tiredness, a rapid heartbeat, easy bruising or bleeding, a new fever, bloody or dark urine, severe abdominal pain, or yellowing of the eyes or skin.

Very serious side effects, although extremely rare, include sudden vision changes, difficulty speaking, loss of consciousness, or seizures. If you experience any of these, seek emergency medical attention right away. Additionally, while a severe allergic reaction to this drug is uncommon, symptoms such as a rash, swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing require immediate medical care. Always communicate with your healthcare provider about any unusual symptoms you encounter during your treatment.

Valacyclovir, marketed as Valtrex, can interact with various medications, which may alter its effects or increase the risk of side effects. It is important to inform your doctor and pharmacist about all medications and supplements, both prescription and over-the-counter, as well as vitamins and herbal supplements that you are currently taking.

Valacyclovir should not be used with Acyclovir-containing medications due to their similarity, which can lead to an overdose. Additionally, caution is advised when taking valacyclovir with other drugs that can affect kidney function, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen and Naproxen, as this might increase the risk of kidney issues.

There are certain medications that are generally not recommended to be used with valacyclovir unless absolutely necessary. These include Dichlorphenamide, Foscarnet, Leflunomide, Nitisinone, and Teriflunomide. If these medications must be used together, your doctor may adjust the doses or frequency of administration.

Moreover, combining valacyclovir with medications like Fosphenytoin, Phenytoin, and Valproic Acid may heighten the risk of side effects. In such cases, your healthcare provider might modify the dosage or frequency of these medications to ensure the safest and most effective treatment. Always consult your healthcare provider before making any changes to your medication regimen.