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This safety and warning information outlines important considerations for anyone taking this medication. It is crucial to understand the potential risks, precautions, and actions to take in specific situations. Always consult your healthcare provider if you have any questions or concerns.

• Blood Disorders: Although rare, some individuals with weakened immune systems have developed serious blood disorders while using acyclovir (Zovirax). Your healthcare provider may conduct blood tests during your treatment to monitor for any issues. Immediately contact your provider if you experience symptoms such as unexplained fever, unusual bleeding or bruising, confusion, fatigue, nausea, vomiting, diarrhea, or dark urine. This risk is particularly relevant for patients with compromised immune systems.

• Kidney Problems: Acyclovir (Zovirax) can potentially cause significant kidney damage, particularly in older adults. The dosage may need adjustment for those with existing kidney issues. The risk increases if you are dehydrated or are taking other kidney-affecting medications, such as NSAIDs like ibuprofen or naproxen. It is important to maintain adequate hydration and consult your healthcare provider before using any additional medications, including over-the-counter pain or cold remedies. Your provider may also order lab tests to assess kidney function. Risks are heightened for individuals aged 65 or older, those with existing kidney issues, or those taking other kidney-impacting drugs.

• Contraindications: This medication should not be used if you have any of the following conditions, as it could result in severe health complications:

  • Allergy to acyclovir (Zovirax) or valacyclovir (Valtrex).
  • Allergy to milk protein concentrate (specific to Sitavig).

In case of overdose or adverse reactions, seek immediate medical assistance. Always keep open communication with your healthcare provider to ensure safe use of the medication.

When using this medication, some individuals may experience mild side effects, including a temporary burning or stinging sensation upon application. These effects are usually short-lived and not a cause for concern. However, if they persist or worsen, it's important to consult a healthcare provider. Common side effects reported include feeling unwell, nausea, vomiting, diarrhea, and headaches. These are generally mild but should be discussed with a healthcare provider if they continue.

There are also other side effects that some users have noted, such as dizziness, low energy, and irritation at the application site. Additionally, rare occurrences of redness and rash have been reported. While these effects are not common, they should be monitored, and any persistent or bothersome symptoms should be discussed with a healthcare provider.

Serious side effects are rare but require immediate medical attention. These include severe allergic reactions characterized by rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing. An application site reaction, though uncommon, is also considered serious and warrants urgent medical care. Always remain vigilant for any unexpected changes in your health while using this medication.

When taking Acyclovir (Zovirax), it is important to inform your doctor and pharmacist about all other medications and supplements you are using, including both prescription and over-the-counter drugs, as well as vitamins and herbal supplements. This is because Acyclovir can interact with certain medications.

Some drugs, such as Dichlorphenamide, Foscarnet, Leflunomide, Nitisinone, and Teriflunomide, are typically not recommended to be used with Acyclovir. However, in some situations, your doctor might decide that using both is necessary, in which case they may adjust the dosage or frequency of one or both medications.

Additionally, using Acyclovir with Fosphenytoin, Phenytoin, or Valproic Acid might increase the risk of side effects. Despite this, your doctor might find that using these medications together is the best option for your treatment. If so, they may modify how often or how much of each drug you take to manage this risk.