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When considering treatment with Abrocitinib, it's essential to be aware of potential risks and necessary precautions to ensure safe use. Below are key safety and warning details to keep in mind:

• Infection Risk: Abrocitinib may impair your immune system, increasing the likelihood of serious infections, including bacterial (e.g., tuberculosis), viral (e.g., herpes), and fungal infections. Patients should be monitored for infections both before and during treatment. Notify your healthcare provider immediately if you develop symptoms such as persistent sore throat, fever, chills, cough, or non-healing skin sores. People with current or recurring infections, those taking immunosuppressive drugs, or those who have traveled to regions with high TB rates should exercise additional caution.

• Cancer Risk: There is a potential risk of developing cancers, such as lymphoma and skin cancer, while taking Abrocitinib. Regular monitoring and annual skin cancer screenings are advised. Use protective measures like sunscreen and avoid UV exposure to reduce skin cancer risk. Individuals with a history of cancer or who smoke may be at increased risk.

• Blood Clots and Cardiovascular Events: Abrocitinib may increase the risk of blood clots, heart attacks, and strokes. Seek immediate medical attention if you experience symptoms such as chest pain, sudden dizziness, severe headache, or difficulty speaking. Individuals over 50, those with high blood pressure, cholesterol, blood sugar, or a smoking history should be particularly cautious.

• Low Blood Cell Counts: This medication can lead to reduced levels of red and white blood cells and platelets, heightening the risk for bleeding, anemia, and infections. Your healthcare provider may conduct regular blood tests to monitor these levels. Report any signs of low blood cell counts, like unusual bleeding or bruising, to your provider promptly.

• Cholesterol Levels: Abrocitinib may elevate cholesterol levels. Regular cholesterol testing is recommended, and individuals with high cholesterol or on cholesterol-lowering medications should inform their provider before starting this treatment.

• Contraindications: Avoid using Abrocitinib if taking antiplatelet medications (except low-dose aspirin) during the initial three months of treatment, as this combination may pose serious health risks. Always consult your healthcare provider if you have concerns or specific pre-existing conditions before beginning treatment.

Patients should discuss the benefits and risks of Abrocitinib with their healthcare provider to make an informed decision and ensure appropriate monitoring throughout the treatment.

When taking this medication, some common side effects might include nausea, headache, dizziness, tiredness, and symptoms resembling a common cold. These effects are usually mild and should not be a cause for concern unless they persist or worsen, in which case consulting a healthcare provider is advisable. Additionally, some users may experience acne, vomiting, mouth and throat pain, high blood pressure, skin rash, and stomach discomfort. These are less common and typically not severe, but monitoring is recommended.

There are, however, rare but serious side effects that require immediate medical attention. These include vision changes such as blurred vision or seeing flashes of light, which are critical signals to seek urgent care. Allergic reactions, though rare, can occur and manifest as a rash, itching, swelling of the face, tongue, or throat, severe dizziness, and trouble breathing. These symptoms necessitate immediate medical intervention.

Very serious conditions like stroke, arterial thrombosis, pulmonary embolism, deep vein thrombosis, and serious bleeds can also occur, though they are uncommon. Symptoms of these conditions include sudden weakness, trouble speaking, chest pain, shortness of breath, leg pain, or bleeding that is difficult to stop. Additionally, serious infections characterized by fever, difficulty breathing, or significant changes in urination patterns require urgent medical care. Always remain vigilant for these serious side effects and seek medical assistance promptly if they occur.