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When using ruxolitinib cream, it is important to be aware of potential risks and necessary precautions. The following information outlines key safety considerations and steps to take if you experience certain symptoms.

• Infection Risks: Ruxolitinib may impair your ability to fight infections, potentially leading to serious or worsening existing infections, including fungal, tuberculosis, and herpes zoster. Report any persistent sore throat, cough, fever, chills, unusual sweating, or painful skin rashes to your healthcare provider immediately.

• Cancer Risk: There have been reports of skin cancer and other cancers, such as lymphoma, in individuals using ruxolitinib. Regular skin examinations and cancer screenings are advised. Use sun protection and avoid UV light exposure to reduce your risk.

• Blood Clots and Cardiovascular Concerns: Users have reported blood clots and heart-related issues. If you experience symptoms such as shortness of breath, chest pain, dizziness, or sudden vision changes, seek medical attention immediately. Discuss your history of heart disease, stroke, or cancer with your doctor before starting treatment, especially if you're over 50 or have risk factors like high blood pressure or diabetes.

• Low Blood Cell Counts: Ruxolitinib can lower red and white blood cell counts and platelets, increasing the risk of bleeding, anemia, and infections. Regular blood tests may be necessary to monitor your cell counts. Notify your doctor if you have symptoms such as unusual bruising or weakness.

• High Cholesterol: While it's unclear if ruxolitinib cream affects cholesterol levels, inform your dermatologist if you have high cholesterol or are on cholesterol-lowering medications. Blood tests may be required to monitor your cholesterol.

• Emergency Situations: In case of overdose or severe reactions, seek emergency medical assistance promptly.

Consult your healthcare provider to thoroughly discuss all risks and benefits before using ruxolitinib cream, especially if you have any pre-existing conditions or are taking other medications.

When taking this medication, it's important to be aware of possible side effects, though many individuals do not experience serious issues. Common side effects include a runny nose, sore throat, bronchitis, ear infections, hives, diarrhea, redness and swelling around hair pores, and swelling of the tonsils. These are typically mild but should be discussed with your healthcare provider if they persist or worsen.

Some users also report side effects such as acne or itching at the application site, headaches, and urinary tract infections. Again, these are generally mild, but if they become bothersome, consulting a healthcare provider is advisable.

There are rare but serious side effects that require immediate medical attention. These include symptoms like fever, blisters or painful rash indicative of shingles, watery eyes, ear pain or hearing loss associated with swimmer's ear, stuffy nose, trouble sleeping, and stomach pain. Additionally, watch for signs of anemia like unusual tiredness and pale skin, as well as easy bleeding or bruising.

A very serious allergic reaction is rare but can occur. Seek emergency medical help if you experience symptoms such as a rash, severe itching or swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing. Always consult your healthcare provider if you notice any other effects not listed here.