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This safety information outlines critical warnings and precautions associated with the use of Stiolto Respimat (tiotropium/olodaterol). Carefully consider these points and discuss any concerns with your healthcare provider.

• Not for Exacerbation Relief: Stiolto Respimat should not be used as a rescue inhaler during COPD exacerbations. If your symptoms, such as coughing and shortness of breath, are worsening, consult your healthcare provider to evaluate whether additional medication is needed.

• Avoid Concurrent Use with LABAs: Do not use Stiolto Respimat alongside other long-acting beta agonists (LABAs) due to the risk of severe complications. When using short-acting beta agonists (SABAs) like albuterol, adhere strictly to the recommended dosage to prevent adverse effects.

• Risk of Bronchospasm: This medication may occasionally cause bronchospasm, resulting in difficulty breathing, wheezing, and chest discomfort. If you experience breathing difficulties after inhalation, use your rescue inhaler and seek immediate medical attention.

• Severe Allergic Reactions: Be alert for signs of severe allergic reactions, such as hives, facial swelling, or difficulty breathing. Seek emergency medical assistance if these symptoms occur. This risk is heightened in individuals allergic to ipratropium, tiotropium, or olodaterol.

• Cardiovascular Concerns: Olodaterol may increase blood pressure and heart rate, potentially affecting heart rhythm. Regular monitoring may be advised if you have pre-existing heart conditions. Do not exceed the prescribed dosage, and inform your healthcare team if you experience dizziness, fatigue, or rapid heartbeat.

• Eye Health: Although rare, this medication can elevate eye pressure, potentially aggravating glaucoma. Avoid contact with the eyes and consult an eye specialist if you notice vision changes. Those with a history of glaucoma should inform their eye care provider about their use of Stiolto Respimat.

• Urinary Issues: Use cautiously if you have urinary or prostate problems, as the medication may worsen urination difficulties. Report any new or worsening urinary symptoms to your healthcare provider.

• Hypokalemia Risk: Overuse can lead to low blood potassium levels, with symptoms like fatigue, muscle cramps, and a racing heart. Follow the prescribed dosage and seek help if breathing does not improve.

Contraindications:

• Do not use for asthma treatment without an inhaled steroid.
• Avoid if allergic to ipratropium, tiotropium, or olodaterol.

This information aims to guide safe use and ensure patient awareness of potential risks. Always consult with your healthcare provider for personalized advice.

When using this medication, some common side effects may occur, but they are typically mild and manageable. These include nervousness, shaking (tremor), trouble sleeping, nose and throat infections, cough, and back pain. If these effects persist or worsen, it's advisable to consult a healthcare provider. Additionally, monitoring your blood pressure is important as this medication may elevate it.

There are other side effects that, while less common, have been reported by some users. These include dizziness, blurry vision, dry mouth, abnormal heartbeat, and rash. If any of these symptoms occur, particularly if they are severe, you should reach out to your healthcare provider.

Serious side effects, though rare, require immediate medical attention. These include sudden narrowing of the airways, indicated by difficulty breathing, wheezing, or chest pain. Heart-related issues such as severe dizziness, fatigue, irregular heartbeat, or worsening of existing heart conditions also fall into this category. Furthermore, a serious allergic reaction may present as hives, swelling of the face, lips, or tongue, and difficulty breathing. In such cases, seek urgent medical care promptly.

Remember, while these side effects are possible, many people do not experience significant issues. If you notice any effects not listed here, it's important to contact your healthcare provider for further guidance.