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This medication has important safety information that you need to be aware of. Please read the following warnings and consult your healthcare provider if you have any questions or concerns.

• Severe Allergic and Skin Reactions: While rare, severe allergic reactions to silver sulfadiazine (SSD) can occur, including life-threatening conditions such as Stevens-Johnson syndrome (SJS) or anaphylaxis. If you experience symptoms like painful blisters, hives, a widespread rash, swelling of the lips or tongue, or breathing difficulties, seek emergency medical help immediately by calling 911. Inform your healthcare provider if you have a known allergy to sulfa medications before starting SSD.

• Changes in Blood Cell Levels: Although uncommon, silver sulfadiazine (SSD) may cause blood-related issues, such as low blood cell levels. Symptoms can include weakness, dizziness, fatigue, and unusual bleeding. Contact your healthcare provider if you experience any of these symptoms.

• Risk of Fungal Infections: Prolonged use of silver sulfadiazine (SSD) may lead to fungal infections at the application site. If you notice increased skin redness, itching, or burning, inform your healthcare provider promptly. Your provider will monitor your condition if long-term use is necessary.

Contraindications: This medication should not be used in the following situations due to potential serious health risks. Consult your healthcare provider if any of these apply to you:

• Pregnant individuals nearing their due date.
• Infants less than 2 months old.

Always communicate with your healthcare provider about your health status and any other medications you are taking to ensure safe use of this medication.

When using this medication, some individuals may experience side effects, which can vary in severity. Commonly, there might be mild discomfort such as pain, burning, or itching of the treated skin. Temporary changes in skin color, such as blue or gray discoloration, may also occur, as well as a mild rash or skin redness. These side effects are typically not severe, but if they persist or worsen, it's advisable to consult a healthcare provider for reassurance and guidance.

In rare cases, more serious side effects can occur and should be addressed immediately. These include signs of infection like a persistent sore throat, fever, or chills, as well as symptoms indicating potential anemia such as unusual tiredness, rapid breathing, or a fast heartbeat. Additionally, signs of kidney or liver problems, such as changes in urine color or amount, persistent nausea, vomiting, or yellowing of the skin or eyes, require prompt medical attention.

An allergic reaction, while uncommon, is a serious concern. Symptoms may include a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, and breathing difficulties. Should any of these symptoms develop, seek urgent medical care. Always be vigilant for any side effects not listed here, and discuss them with your healthcare provider to ensure your safety and well-being.

Some medications and substances can interact with Silver sulfadiazine (SSD). It is important to inform your doctor and pharmacist about any other medications, supplements, or skin products you are using.

Certain skin products containing sodium sulfacetamide, as well as enzyme products like Collagenase, Papain, and trypsin, may interact with SSD. Additionally, an ingredient in some forms of this medication, Propylene Glycol, might affect lab tests, potentially leading to inaccurate results. Ensure that your healthcare providers and lab technicians are aware you are using SSD to prevent any test misinterpretations.

Silver sulfadiazine (SSD) should not be used with Methenamine, as this combination is not recommended. If you are using Methotrexate, your doctor might adjust your medication regimen since combining it with SSD is typically not advised unless necessary. Furthermore, when SSD is used along with aminolevulinic acid, there may be an increased risk of side effects, but in some cases, using both could be beneficial. Your doctor may need to adjust the dosages or the frequency of these medications.