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Silver sulfadiazine is a prescription antibiotic cream primarily used to prevent and treat serious skin infections resulting from second- and third-degree burns. It functions by halting the growth of bacteria, thereby reducing the risk of infections spreading to nearby skin or entering the bloodstream, which can lead to sepsis. The cream is typically applied once or twice daily after cleaning the wound. While effective, it may cause side effects such as a rash, skin redness, or, on rare occasions, serious allergic reactions. It is important to note that silver sulfadiazine should not be used on premature infants or newborns in their first two months due to potential serious side effects. Always consult with your healthcare provider before using this medication to ensure it is safe and appropriate for your condition.