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This document outlines vital safety information regarding the use of Sulfatrim (sulfamethoxazole/trimethoprim). It is crucial to carefully consider these warnings and consult with your healthcare provider if you have any concerns or questions.

• Pregnancy Risks: Sulfatrim is not recommended for use during pregnancy due to potential severe developmental harm to an unborn child. Inform your healthcare provider if you are pregnant, planning to become pregnant, or if you become pregnant while taking this medication to discuss safer alternatives.

• Allergic and Skin Reactions: There is a possibility of severe allergic reactions, including life-threatening conditions like facial swelling and anaphylaxis. Additionally, rare but serious skin reactions, such as Stevens-Johnson syndrome (SJS) and DRESS syndrome, can occur. Be cautious if you have a sulfa allergy.

• Blood Cell Concerns: This medication may lower platelet counts, increasing the risk of serious bleeding, especially when combined with other medications like aspirin or warfarin. Typically, platelet levels return to normal within a week after discontinuation.

• C. difficile Infection Risk: Usage of Sulfatrim may lead to overgrowth of Clostridioides difficile (C. diff) in the intestines, causing severe diarrhea. This is due to changes in normal gut bacteria caused by the antibiotic.

• Electrolyte Imbalance: High doses can result in elevated potassium and decreased sodium levels. Seek immediate medical attention if you experience symptoms such as weakness, numbness, headache, confusion, or memory issues.

• Blood Cell-related Issues: Individuals with certain genetic conditions, like G6PD deficiency, or those with kidney, liver problems, or poor nutrition may experience blood cell damage. Older adults and regular alcohol consumers should also exercise caution.

• Phenylketonuria (PKU) Considerations: People with PKU should maintain a low-protein diet while taking Sulfatrim, as it may exacerbate difficulties in processing phenylalanine.

Contraindications: Avoid using this medication if you have any of the following conditions, as they pose significant health risks:

• Allergy to sulfa drugs
• History of low platelet counts with trimethoprim or sulfa medications
• Megaloblastic anemia due to low folic acid
• Severe liver or kidney problems
• Age under 2 months
• Concurrent use of dofetilide (Tikosyn)

Always consult your healthcare provider for guidance tailored to your personal health needs, and report any adverse reactions or concerns immediately.

When taking this medication, you may encounter some common side effects that are generally mild, such as nausea, vomiting, diarrhea, loss of appetite, rash, hives, and increased sensitivity to sunlight. These effects often resolve on their own, but if they persist or become bothersome, consider reaching out to a healthcare professional.

In addition to the common side effects, other reactions can occur, including muscle and joint pain, fatigue, weakness, difficulty sleeping, and changes in blood sugar levels. While these are less frequent, you should consult a healthcare provider if they cause discomfort or concern.

There are also rare but serious side effects that demand immediate medical attention. These include severe allergic reactions characterized by hives, blisters, and swelling of the lips or tongue, as well as difficulty breathing. Another critical condition is infectious diarrhea, which is associated with symptoms like rapid heart rate, fever, and foul-smelling diarrhea. Additionally, be vigilant for signs of high potassium levels, such as muscle cramps, or low sodium levels, which can cause confusion and seizures. Kidney issues may also manifest as decreased urination or unexplained swelling and weight gain. In the face of any severe side effects, it is crucial to seek urgent medical care.