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Taking nitrofurantoin might cause mild side effects such as nausea, vomiting, loss of appetite, or headaches. Consuming this medication with food can help ease nausea. If these side effects persist or worsen, it's important to inform your healthcare provider. A common, harmless side effect is a change in urine color to dark yellow or brown, which typically resolves after stopping the medication. However, dark brown urine might also signal rare conditions like liver issues or anemia. Seek medical attention if you experience persistent nausea, vomiting, abdominal pain, yellowing of the eyes or skin, fatigue, or a rapid heartbeat alongside dark urine.

It's crucial to monitor for any severe side effects, including persistent or severe headaches, eye pain, vision changes, mood alterations, signs of infection such as a persistent sore throat or fever, and unusual bruising or bleeding. Immediate medical help is necessary if you experience numbness or tingling in your hands or feet, or unusual muscle weakness, as these could indicate very serious conditions.

Rarely, nitrofurantoin may lead to serious lung problems, which can develop early in treatment or after extended use. Symptoms to watch for include a persistent cough, chest pain, difficulty breathing, joint or muscle pain, and skin discoloration. Additionally, this medication might cause a severe intestinal condition due to C. difficile bacteria. If you develop ongoing diarrhea, abdominal pain, or notice blood or mucus in your stool, contact your healthcare provider immediately and avoid anti-diarrhea or opioid products.

Long-term or repeated use of nitrofurantoin may result in oral thrush or a vaginal yeast infection. Notify your healthcare provider if you observe white patches in your mouth or changes in vaginal discharge. Although a severe allergic reaction to this medication is rare, seek immediate help if you experience rash, itching or swelling, severe dizziness, or difficulty breathing.

This summary does not cover all potential side effects. If you notice other unusual symptoms, consult your healthcare provider.