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You may experience mild side effects such as nausea, vomiting, diarrhea, stomach pain, cramping, or loss of appetite. Taking the medication with food can help alleviate these symptoms. If these effects persist or worsen, it is important to consult your healthcare provider.

Serious side effects, though uncommon, require immediate medical attention. These include signs of liver problems such as persistent nausea or vomiting, yellowing of the eyes or skin, dark urine, severe abdominal pain, unusual tiredness, muscle weakness, trouble speaking, blurred vision, drooping eyelids, or hearing loss.

Seek urgent medical help if you experience severe dizziness, fainting, or a rapid or irregular heartbeat. A rare but serious condition called C. difficile-associated diarrhea may occur during or after treatment. Symptoms include persistent diarrhea, abdominal pain, and blood or mucus in your stool. Avoid anti-diarrhea or opioid products as they may worsen these symptoms.

Prolonged use of this medication may lead to oral thrush or a yeast infection. Look out for white patches in the mouth or changes in vaginal discharge and contact your doctor if these occur. Though rare, serious allergic reactions can happen. Seek immediate help if you notice a rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, or trouble breathing.

This summary does not include all possible side effects. If you notice other symptoms, contact your healthcare provider for advice.

This medication can interact with several other drugs. For instance, Digoxin may have an interaction. Additionally, many drugs, not just Erythromycin, can influence heart rhythm and cause QT prolongation. These include Amiodarone, Dofetilide, Pimozide, procainamide, Propafenone, quinidine, and Sotalol, among others.

Some medications can alter how erythromycin is cleared from your body, impacting its effectiveness. Such drugs include azole antifungals like Itraconazole and Ketoconazole, certain calcium channel blockers like diltiazem and Verapamil, and some anti-seizure medications like Carbamazepine and Phenytoin.

Erythromycin itself can also slow the elimination of other drugs from your body, affecting their function. Notable examples are Bromocriptine, Colchicine, certain benzodiazepines such as Midazolam and Triazolam, Eletriptan, ergot alkaloids like ergotamine and Dihydroergotamine, medications for erectile dysfunction or pulmonary hypertension such as Sildenafil and Tadalafil, certain statins like Lovastatin and Simvastatin, and vinblastine.

Moreover, this drug might interfere with specific lab tests, such as urine tests, potentially leading to inaccurate results. Ensure that all healthcare providers and laboratory staff are aware that you are taking this medication.