Trimethoprim

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Trimethoprim is an antibiotic primarily used to treat urinary tract infections (UTIs). It functions by inhibiting the growth of bacteria, effectively stopping them from producing folic acid, which is essential for their survival. It is important to note that Trimethoprim specifically targets bacterial infections and is ineffective against viral infections, such as the common cold or flu. Misuse or overuse of antibiotics can lead to reduced effectiveness in future treatments. Trimethoprim is generally taken orally in tablet form, either once or twice a day. Some common side effects include skin rash and itching. Always consult with your healthcare provider before starting any new medication to ensure it is appropriate for your condition.
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100MG, Trimethoprim (30 Tablets)

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CVS

$21.30

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$22.62

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$49.00

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$51.64

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$66.50

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CVS

$21.30

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Trimethoprim dosage forms

The average cost for 30 Tablets of Trimethoprim at 100MG is $9.96 with a free coupon. This is 8.78% off the average retail price of $113.42
DosageQuantityPrice fromPer unit
100MG30 Tablets$9.96$0.33

Trimethoprim Warnings

This document outlines critical safety information and warnings regarding the use of trimethoprim. Please read carefully and consult your healthcare provider if you have any questions or concerns.

  • Serious Allergic Reactions: Although uncommon, trimethoprim may cause severe allergic reactions, including potentially life-threatening conditions such as severe skin reactions and anaphylaxis, which might lead to throat constriction. If you have a known allergy to antibiotics, inform your healthcare provider to ensure trimethoprim is safe for you. Seek immediate medical assistance if you experience symptoms like hives, rash, red or peeling skin, swelling of the lips or tongue, or difficulty breathing after taking this medication.

  • Clostridioides difficile Infection: The use of antibiotics, including trimethoprim, increases the risk of developing an infection by Clostridioides difficile (C. diff), a bacterium that can cause severe diarrhea, which may be life-threatening. Antibiotics can alter the normal bacterial balance in your digestive system, potentially leading to an overgrowth of C. diff.

  • Development of Drug-Resistant Bacteria: It is crucial to take trimethoprim exactly as prescribed. Deviating from the prescribed dosage or using it for unapproved conditions increases the risk of developing drug-resistant bacteria, which can cause serious infections that are challenging to treat.

For contraindications, trimethoprim should not be used in individuals with anemia due to folic acid deficiency. If this condition applies to you, discuss alternative treatments with your healthcare provider before using this medication.

Trimethoprim Side Effects

Common side effects:

  • Diarrhea
  • Nausea
  • Vomiting
  • Stomach upset
  • Loss of appetite
  • Changes in taste
  • Headache
  • Rash
  • Itching

Less common but important to monitor:

  • Stomach pain
  • Skin sensitivity to sunlight
  • Oral thrush
  • New yeast infection
  • Signs of liver disease
  • Severe drowsiness
  • Muscle weakness
  • Unusual tiredness
  • Low blood sugar symptoms

Serious side effects:

  • Severe allergic reaction
  • Infectious diarrhea caused by C. difficile
  • Seizures

Trimethoprim Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Trimethoprim FAQs
What is the drug trimethoprim used for?

Trimethoprim is used primarily to treat bacterial infections, particularly urinary tract infections. It works by inhibiting the growth of bacteria.

Trimethoprim is not the same as Bactrim, but it is one of the components of Bactrim. Bactrim is a combination antibiotic that contains both trimethoprim and sulfamethoxazole.

Trimethoprim is considered a moderate-strength antibiotic. It is often used in combination with sulfamethoxazole to enhance its effectiveness against a broader range of bacterial infections. On its own, trimethoprim is primarily effective against certain types of bacteria, particularly those causing urinary tract infections.

Trimethoprim is effective against a variety of bacteria, primarily targeting Gram-positive and some Gram-negative organisms. It is commonly used to treat infections caused by bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus saprophyticus. It is also effective against some strains of Streptococcus pneumoniae and Haemophilus influenzae.

The choice of antibiotic for a urinary tract infection (UTI) depends on several factors, including the specific bacteria causing the infection, the patient's medical history, and local antibiotic resistance patterns. Commonly prescribed antibiotics for UTIs include nitrofurantoin, trimethoprim-sulfamethoxazole, and fosfomycin. In some cases, fluoroquinolones like ciprofloxacin may be used, but they are generally reserved for more complicated infections due to concerns about resistance and side effects. It is important for a healthcare provider to determine the most appropriate antibiotic based on individual circumstances.